This trial is active, not recruiting.

Condition acute myocardial infarction
Treatment snowfall > 5cm/day
Sponsor Medical University of Graz
Start date January 2007
End date June 2017
Trial size 12000 participants
Trial identifier NCT02913820, EK28-433ex15/16


Changes in the ambient temperature (esp. warm to cold) as well as exercise are triggers for vasospasms and plaque rupture. Weather data (temperature, precipitation in general as well as snowfall and changes in atmospheric pressure) will be correlated with the incidence of myocardial infarctions.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Observational model cohort
Time perspective retrospective
impact of snowfall and its correlation with acute myocardial infarctions is analyzed. Other precipitation (rainfall) changes in atmospheric pressure and temperature will be variables to be corrected for.
snowfall > 5cm/day
the number of myocardial infarctions of every day analysed in this study will be correlated with the respective values of snowfall

Primary Outcomes

myocardial infarction
time frame: 1 day

Eligibility Criteria

All participants from 18 years up to 99 years old.

Inclusion Criteria: - myocardial infarction being confirmed or treated in the cathlab Exclusion Criteria:

Additional Information

Official title Association of Snowfall and Myocardial Infarction
Description Besides classical cardiovascular risk factors such as smoking, obesity, elevated cholesterol levels and diabetes there are also acute factors potentially triggering acute coronary events. The impact of air temperature (changes) or humidity are of potential relevance. In addition, exercise and the associated increase in oxygen demand of the myocardium and blood pressure is another trigger for plaque rupture and the acute onset of myocardial infarction. Male patients as well as patients with previous coronary heart disease or little regular exercise are at increased risk. Possible additional mechanisms of exercise induced myocardial infarction are vasospasm and changes in blood clotting. Changes in the ambient temperature (warm to cold) can also induce vasospasm which might result in reduced perfusion and plaque rupture. It seems that male patients are more involved than female patients. Taking the exercise and the ambient temperature changes into consideration, heavy snowfall with consecutive snow shoveling is an augmented risk for acute myocardial infarction. The rationale of the study is to test if the above mentioned constellation of environmental factors as well as potential increased exercise have a significant and independent impact on the incidence of myocardial infarctions
Trial information was received from ClinicalTrials.gov and was last updated in January 2017.
Information provided to ClinicalTrials.gov by Medical University of Graz.