This trial is active, not recruiting.

Condition chronic obstructive pulmonary disease
Sponsor Laval University
Collaborator Canadian Institutes of Health Research (CIHR)
Start date February 2013
End date April 2015
Trial size 100 participants
Trial identifier NCT02903043, MIR-20895


Limb muscle dysfunction, characterized by loss of capillaries, is amongst the most troublesome systemic consequences of chronic obstructive pulmonary disease (COPD) leading to poor functional status and premature mortality.

One prevailing hypothesis stipulates that modification in the expression of miR-204 leads to change the regulation of angiogenesis in vastus lateralis of patients with COPD when compared to controls.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Observational model cohort
Time perspective prospective
Quadriceps biopsies will be done. No drug administration.
Quadriceps biopsies will be done. No drug administration.

Primary Outcomes

miR-204 in limb muscles in patients with COPD
time frame: At baseline (COPD patients in a stable state of the disease)

Secondary Outcomes

microRNAs in limb muscles of patients with COPD
time frame: At baseline (COPD patients in a stable state of the disease)

Eligibility Criteria

Male or female participants from 50 years up to 80 years old.

Inclusion Criteria: - COPD (FEV1/FVC < 0.70) - Healthy subjects: no evidence of airways obstruction (FEV1/FVC > 0.70 and FEV1 > 0.80 predicted) - Smoking history > 10 pack-years - Ex-smoker >6 months Exclusion Criteria: - Chronic hypoxemia and/or hypercapnia (PaO2 < 60 mmHg or SpO2 < 88% at rest and/or PaCO2 > 45 mmHg) - Recent exacerbation or oral corticosteroids (< 2 months) - Recent cancer (< 3 years) - Diabetes - Myopathy, neuromuscular, neurological or articular diseases - Kidney disease - Other respiratory diseases - Unstable cardiac disease - Physical activity score > 9 in the Voorips questionnaire - BMI > 30

Additional Information

Official title Expression of miR-204 and Consequences on Capillarization in Limb Muscles of Patients With Chronic Obstructive Pulmonary Disease
Description The investigators objective is to investigate the impact of COPD on key signaling pathways involved in the muscle angiogenesis. Mild to severe COPD patients and healthy controls will be recruited. All of the investigators patients will undergo a thorough baseline assessment in pulmonary capacity and body composition. Blood sampling and biopsy of the quadriceps will be done. Key proteins and microRNAs of signaling intramuscular pathways involved in angiogenesis will be measured in the quadriceps.
Trial information was received from ClinicalTrials.gov and was last updated in September 2016.
Information provided to ClinicalTrials.gov by Laval University.