Association Between Different Parameters of Nutritional Assessment and Clinical Outcomes in Cancer Patients
This trial is active, not recruiting.
|Conditions||cancer, postoperative complications, sarcopenia|
|Sponsor||Federal University of Minas Gerais|
|Start date||March 2013|
|End date||July 2016|
|Trial size||120 participants|
|Trial identifier||NCT02901132, FUMinas Gerais|
Malnutrition in oncologic patients has a negative impact on post- surgical recovery, survival and quality of life. The etiology of malnutrition in cancer patients is multifactorial, therefore, the nutritional assessment should be carried out by different parameters. The objective of this study is to investigate the association and prognostic value of five distinct methods of nutritional assessment (molecular, body composition, functional, anthropometric and subjective) in relation to postoperative complications and short-term survival in patients with cancer. Regarding the molecular parameter, mtor signaling pathwayon will be assessed in rectus muscle samples, harvested in the moment of the operation. Body composition was assessed by computed tomography (CT) and bioelectrical impedance test was conducted to evaluate the phase angle. Handgrip strength was used to determine functionality. The percentage of weight loss in relation to usual weight was the anthropometric parameter used. Subjective Global Assessment (SGA) was used to provide the nutritional diagnosis. Postoperative complications were classified according to the Dindo and Clavien classification. Overall time survival was the period between the first assessment of the patients until death or end of follow-up. Chi-square test, t test, Kaplan-Meier method and the Log Rank test and regression analysis will be used (p <0.05).
|United States||No locations recruiting|
|Other Countries||No locations recruiting|
Colorectal cancer patients, under 18 years old, no inflammatory disease, weight loss greater 10% habitual body weight, sarcopenic.
No cancer patients, under 18 years old, no inflammatory disease, no weight loss, no sarcopenic.
time frame: August, 2016
time frame: July, 2016
Male or female participants at least 18 years old.
Inclusion Criteria: - Diagnostic cancer confirmed - Over 18 years old - Accepted the terms of survey Exclusion Criteria: - Tumor synchronic - Inflamattory disease - Under 18 years old - No accepted the terms of survey
|Official title||Association Between Different Parameters of Nutritional Assessment and Clinical Outcomes in Cancer Patients|
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