Association of Air Quality and Myocardial Infarction
This trial is active, not recruiting.
|Condition||acute myocardial infarction|
|Sponsor||Medical University of Graz|
|Start date||January 2007|
|End date||December 2016|
|Trial size||12000 participants|
|Trial identifier||NCT02880436, 28-292ex15/16|
Besides classical cardiovascular risk factors such as smoking, obesity, elevated cholesterol levels and diabetes there are also acute factors potentially triggering acute coronary events. The impact of various substances and air pollution are described.
Particulate matter, especially with small particle size (<2.5µm) has been shown to have a positive correlation with myocardial infarctions. However, other studies failed to show this correlation.
With respect to nitric oxydes the majority of published studies detected a significant correlation with myocardial infarction, too, although a highly ranked publication failed to show the same result. In addition data on the impact of sulfur dioxide and carbon monoxide concentration on cardiac events is very heterogeneous.
Published data indicates additive effects of age and other epidemiological variables suggesting the need of a multivariate analysis.
The rationale of the study is to test if the above mentioned air pollution factors have a significant and independent impact on the incidence of myocardial infarctions
time frame: 1 day
Male or female participants from 18 years up to 99 years old.
Inclusion Criteria: - myocardial infarction being confirmed or treated in the cathlab Exclusion Criteria:
|Official title||Association of Air Quality and Myocardial Infarction|
|Principal investigator||Dirk von Lewinski, MD|
|Description||The analysis will be performed in a well characterized patient cohort of 12.000 myocardial infarctions within 10 years being invasively diagnosed at the catheterisation centers of the styrian capital Graz.|
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