This trial is active, not recruiting.

Condition kawasaki disease
Treatment laboratory biomarker analysis
Sponsor Hospices Civils de Lyon
Start date September 2011
End date December 2015
Trial size 75 participants
Trial identifier NCT02853266, 69HCL16_0477


Kawasaki disease (KD) is an acute systemic vasculitic syndrome with coronary tropism. It has been reported worldwide, but it is ten times more common in Asian population. It is the second vasculitis of the child by its frequency after rheumatoid purpura. It occurs in 80% of cases between 1 and 5 years, with a maximal incidence around the age of 12 months.

KD is not well understood and the cause is yet unknown. It may be an autoimmune disorder. The problem affects the mucous membranes, lymph nodes, walls of the blood vessels, and the heart.The clinical picture of KD associate a persistent fever and an antipyretics resistance with mucocutaneous signs and bulky cervical lymphadenopathy usually unilateral.

There is currently no vaccine available against Kawasaki disease so it is extremely important to be able to recognize symptoms before they set in and become too severe.

Chagas disease (CD) is caused by the parasite Trypanosoma cruzi. Acute CD occurs immediately after infection, may last up to a few weeks or months. Infection may be mild or asymptomatic. There may be fever or swelling around the site of inoculation, and acute infection may result in severe inflammation of the heart muscle. The notion that the pathology of CD has an autoimmune component was initially based on the finding of circulating antibodies binding heart tissue antigens in patients chronically infected with T. cruzi.

A recent study reports a possible antigen (non-cruzi-related antibody NCRA) mimicry characterized by a serological reactivity to a well-defined T. cruzi antigen in blood samples from individuals not exposed to the parasite. The measured seroprevalence of such cross-reactivity is in favor of a highly prevalent immunogen acquired in childhood.

There are similarities in mechanism of CD and KD: it could be interesting to explore the presence of NCRA in blood samples from adults with a history of KD.

The objective of the study is the measurement of the biomarker NCRA in serum in adults with a history of KD compare to a control population. This measurement and the prevalence may permit to associate the NCRA to a possible pathogenic agent.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Observational model cohort
Time perspective prospective
adults with a history of KD in childhood
laboratory biomarker analysis
Archived serum samples are analysed for measurement of biomarker NCRA
healthy adults volunteers
laboratory biomarker analysis
Archived serum samples are analysed for measurement of biomarker NCRA

Primary Outcomes

Prevalence of NCRA in the KD population vs control population.
time frame: at recruitment time. (Day 0)
NCRA concentration in the KD population vs control population.
time frame: at recruitment time. (Day 0)

Eligibility Criteria

Male or female participants from 18 years up to 65 years old.

Inclusion Criteria: - History of KD before the age of 18, with or without macroscopic coronary lesions in the childhood phase. (KD group only) - 18 years old or older at the time of the study. - Agree on participating to all explorations of the study. - Accept genotyping. - Absence of cardiovascular risk factors Exclusion Criteria: - - Atypical KD (KD group only) - Documented or suspected coronary ischemia, - Refusal to participate to the study or sign the consent - Contra-indication to the injection of iodinated contrast agents (allergy, renal failure) - Hypersensitivity to dobutamine, - No effective contraception method for females with child bearing potential, - Breastfeeding, or pregnant females, - Treatment modifying endothelial reactivity - History of severe intolerance to iodinated contrast agents, - Subjects who can't hold their breath for at least 20 seconds, - Irregular or absence of sinus rhythm, especially atrial or ventricular arrhythmia - Unability to give information to the subject, - No coverage from a Social Security system - Deprivation of civil rights

Additional Information

Official title Measurement of Antibodies in Adults With a History of Kawasaki Disease
Principal investigator François Gueyffier, Pr
Trial information was received from ClinicalTrials.gov and was last updated in July 2016.
Information provided to ClinicalTrials.gov by Hospices Civils de Lyon.