Pharmacokinetics of Vancomycin in ICU Patients
This trial is active, not recruiting.
|Condition||suspected infection with vancomycin susceptible bacterial strains|
|Sponsor||Hospices Civils de Lyon|
|Start date||October 2015|
|End date||July 2016|
|Trial size||80 participants|
|Trial identifier||NCT02844192, 69HCL16_0452|
Vancomycin is frequently under-dosed in ICU patients during the first 24-48 hours of treatment. Glomerular hyperfiltration syndrome, increased drug volume of distribution, vasopressor use, male sex and hypoalbuminemia are identified risk factor for vancomycin underdosing in ICU patients, among others.
To date, bedside estimation of vancomycin volume of distribution is challenging, and new methods for optimizing drug administration are required.
The Picco device is a moderately invasive hemodynamic monitoring system, providing parameters that may help estimation of vancomycin pharmacokinetics parameter.
The aim of this study is to test whether addition of hemodynamic parameters would improve pharmacokinetics modelling of vancomycin concentration in ICU patients.
|United States||No locations recruiting|
|Other countries||No locations recruiting|
Akaike information criterion as a measurement of goodness of fit of pharmacokinetic modeling of vancomycin serum concentration
time frame: week 1
Rate of patients with under-dosage of vancomycin at day 2 of treatment
time frame: day 2
Male or female participants at least 18 years old.
Inclusion Criteria: - patient hospitalized in intensive care unit - under intravenous vancomycin started during current ICU hospitalization - with at least one vancomycin serum concentration available - under hemodynamic monitoring with the Picco ® device Exclusion Criteria: - vancomycin treatment for less than 24 hours - vancomycin concentration in serum unavailable - rare comorbidities influencing vancomycin pharmacokinetics - myeloma - cystic fibrosis - burn injury on more than 20 % of the body surface - previous inclusion in present study
|Official title||Pharmacokinetics of Vancomycin in ICU Patients|
|Principal investigator||Jean-Christophe RICHARD, Prof|
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