This trial has been completed.

Condition weight-lifting exercise program
Treatments lower-repetition, heavier-load, higher-repetition, lighter-load
Sponsor McMaster University
Start date September 2014
End date August 2016
Trial size 60 participants
Trial identifier NCT02842593, REB 14-333-1


This study evaluates the effects of two types of resistance exercise training (higher-repetition, lower load vs lower-repetition, higher load vs control) on regional and local measures of arterial stiffness in trained young men.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Allocation randomized
Intervention model parallel assignment
Masking open label
Primary purpose basic science
Whole-body resistance exercise training 4x/week for 12 weeks. Either 'lower-repetition, heavier-load' or 'higher-repetition, lighter-load' intervention.
lower-repetition, heavier-load
8-12 reps/set at ~80% 1 repetition maximum
higher-repetition, lighter-load
20-25 reps/set at ~30% 1 repetition maximum
(No Intervention)
Continue habitual physical activity for 12 weeks.

Primary Outcomes

Carotid-femoral pulse wave velocity
time frame: 12 weeks post exercise training

Secondary Outcomes

Common carotid artery distensibility
time frame: 12 weeks post exercise training
Left ventricular mass
time frame: 12 weeks post exercise training

Eligibility Criteria

Male participants from 18 years up to 30 years old.

Inclusion Criteria: - Male - Aged 18-30 years old - Non-obese (Body mass index less than 30 kg/m2) - Non-smoker - Healthy based on questionnaire responses - Resistance trained (Resistance training > 2 times per week for 2 years, minimum 1 lower body exercise session per week) Exclusion Criteria: - Allergies to milk proteins (whey or casein) - Any acute or chronic illness, cardiac, pulmonary, liver, or kidney abnormalities, uncontrolled hypertension, insulin- or non-insulin dependent diabetes or other metabolic disorders-all ascertained through medical history screening questionnaires - Arthritic conditions - Individuals who consume any analgesic or anti-inflammatory drug(s), prescription or non- prescription, chronically will be excluded - A history of neuromuscular problems - Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications).

Additional Information

Official title Vascular Responses to High vs Low Repetition Resistance Exercise Training in Young Men
Principal investigator Stuart M Phillips, PhD
Trial information was received from ClinicalTrials.gov and was last updated in January 2017.
Information provided to ClinicalTrials.gov by McMaster University.