Potential Diagnostic and Prognostic Value of microRNAs for the Patients of Sepsis-induced Myocardial Injury
This trial is active, not recruiting.
|Condition||sepsis-induced myocardial injury|
|Sponsor||Xinhua Hospital, Shanghai Jiao Tong University School of Medicine|
|Start date||April 2016|
|End date||December 2018|
|Trial size||100 participants|
|Trial identifier||NCT02835573, XH-16-018|
The purpose of this study is to evaluate the potential diagnostic and prognosis value of circulating microRNAs compared with cTnI for the patients of sepsis-induced myocardial injury at the emergency department (ED) and intensive care unit (ICU).
Patients admitted to the hospital with the diagnosis of Sepsis-induced myocardial injury
Patients admitted to the hospital without the diagnosis of Sepsis-induced myocardial injury
Diagnostic value of microRNAs evaluate by qPCR in patients of sepsis-induced myocardial injury
time frame: Day 7
Prognostic value of microRNAs in patients of sepsis-induced myocardial injury
time frame: 6 months
Male or female participants of any age.
Inclusion Criteria: 1. Diagnosis of sepsis:SOFA score increase >=2 at baseline level induced by infection. 2. Suspected myocardial injury,including 1 as follows at least:Low blood pressure or using vasoactive drugs; ECG changes(ST segment changes or pathological Q wave); Troponin elevation(> 0.5 μg/L); BNP elevation(> 4670pg/ml); Echocardiography: cardiac function decline(EF<50%). Exclusion Criteria: 1. Skeletal muscle damage (induced by orthopedics, vascular surgery or trauma surgical disease, surgery); 2. Pregnant and lactating women; 3. Patients with mental disorders; 4. Patients are using other experimental drugs; 5. Refusal to provide informed consent
Call for more information