Overview

This trial is active, not recruiting.

Conditions systemic inflammatory response syndrome, ventilator weaning
Sponsor Beijing Chao Yang Hospital
Start date May 2014
End date April 2017
Trial size 300 participants
Trial identifier NCT02820090, 15210511726

Summary

Infection and trauma take a important role in the acute respiratory failure.There are different causes and degrees of inflammatory reaction in the critically ill patient. The inflammatory reaction should also affect patients on mechanical ventilation dependence with body physiological response and disease prognosis in patients. Therefore, the investigators hypothesize that inflammation may have an important role in the prediction of weaning from mechanical ventilation.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Observational model case control
Time perspective prospective
Arm
The patient have a success in SBT.
Weaning from mechanical ventilation is successful
The patient have a failure in SBT.
Weaning from mechanical ventilation is failed

Primary Outcomes

Measure
The relationship between mechanical ventilation of ventilator and inflammatory response
time frame: January 2014 to December 2016

Secondary Outcomes

Measure
The relationship between diaphragm movement function and weaning from mechanical ventilation
time frame: January 2016 to December 2017
the output of CO2
time frame: January 2016 to December 2017

Eligibility Criteria

Male or female participants from 14 years up to 80 years old.

Inclusion Criteria: - oral, nasal tracheal intubation and mechanical ventilation in patients with respiratory failure - mechanical ventilation time over than 48 hours - Glasgow score greater more than or equal to 13 points Exclusion Criteria: - Aged less than 14 years or more than 80 years old - patients with neuromuscular disease - pure heart failure pulmonary edema patients - patients with tracheotomy

Additional Information

Official title The Predictive Effect of the Inflammatory Response on the Evacuation of Mechanical Ventilation and the Mechanism
Description In the process of mechanical ventilation, the patients were divided into two groups according to the failure of spontaneous breathing test and spontaneous breathing test.In the index of predicting mechanical ventilation, the investigators will take the index of inflammatory response, the function index of diaphragm and the amount of exhaled CO2 into account to reduce the failure rate of mechanical ventilation.
Trial information was received from ClinicalTrials.gov and was last updated in June 2016.
Information provided to ClinicalTrials.gov by Beijing Chao Yang Hospital.