Heart Failure Ventricular Pressure Time Profile
This trial has been completed.
|Treatments||ntprobnp, echocardiography, arterial tonometry|
|Sponsor||National Heart Centre Singapore|
|Start date||May 2013|
|End date||February 2017|
|Trial size||75 participants|
|Trial identifier||NCT02791074, 2013/365/C|
This proposed study aim to:
1. Determine intra-LV pressure-time profile non-invasively using recently developed echo Doppler VFM analysis and applanation tonometry and myocardial elastic properties, in HF subjects (both HFNEF and HFREF) compared to normal volunteers.
2. Correlate calculated intra-LV pressure parameters with NT ProBNP levels.
First occurrence of cardiovascular event
time frame: 1 Year
All participants from 21 years up to 90 years old.
Inclusion Criteria: - Either 1. has presented to hospital with a primary diagnosis of Heart Failure or 2. is attending a hospital clinic for management of Heart Failure within 6 months of an episode of decompensated heart failure, which either: - resulted in a hospital admission (primary diagnosis) or - was treated in out-patient clinic - LVEF >50% is used as cut-off value for HFNEF and LVEF < 50% for HFREF. - NT-proBNP within 7 days of admission > 220pg/ml. If there is no result available, NT-proBNP on the same day as echo scan must be > 220pg/ml. Exclusion Criteria: - Haemodynamically significant valve disease defined as more than mild degree of valve stenosis, or more than moderate degrees of mitral or aortic valve regurgitation. - History of valvular disease, i.e. rheumatic heart disease and/or having undergone valvular replacement. - Isolated right heart failure due to pulmonary disease. - Presence of haemodynamically significant obstructive lesions of left ventricular outflow tract. - History of any organ transplant or who was on a transplant list (life expectancy < 6 months at time of enrollment). - Presence of end-stage renal failure. - Pregnancy. - The patient is unable to provide written informed consent.
|Official title||Non-invasive Determination of Intra-left Ventricular Pressure-time Profile for Diagnosis of Heart Failure With Normal and Reduced Ejection Fraction.|
|Principal investigator||Thu Thao Le, PHD|
|Description||Heart failure (HF) is a common disease and its syndrome is difficult to diagnose. HF with reduced ejection fraction (HFREF) may be diagnosed based on impaired LVEF (<50%). However, diagnosis of HF with normal ejection fraction (HFNEF) is mainly based on the presence of signs and symptoms. Central to diagnosis of HF is estimation of intra-cardiac pressure, which can only be obtained from invasive catheterization. This proposed study aim to: 1. Determine intra-LV pressure-time profile non-invasively using recently developed echo Doppler VFM analysis and applanation tonometry and myocardial elastic properties, in HF subjects (both HFNEF and HFREF) compared to normal volunteers. 2. Correlate calculated intra-LV pressure parameters with NT ProBNP levels.|
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