This trial is active, not recruiting.

Conditions energy expenditure, obesity, adipose tissue, brown
Treatments cold air, cold water
Sponsor Clinical Nutrition Research Centre, Singapore
Collaborator Institute for Infocomm Research
Start date November 2014
End date July 2016
Trial size 20 participants
Trial identifier NCT02790255, 2014/00721


The whole body calorimeter is sensitive enough to reliably measure cold-induced thermogenesis as a surrogate marker of brown adipose tissue (BAT) activation.

The infrared (IR) energy flux from activated BAT can be accurately imaged and quantified using an IR imaging device, and that this IR energy output may be correlated to the increased energy expenditure quantified by the whole body calorimeter.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Allocation non-randomized
Intervention model crossover assignment
Masking open label
Subjects to be seated in an airtight chamber at an ambient temperature between 16 to 20 degrees Celsius for 1 hour.
cold air
Subjects to be seated in an airtight chamber at an ambient temperature of 24 degrees Celsius, with their hands and feet fully immersed in cold water for 5 minutes.
cold water

Primary Outcomes

Temperature at cervical-supraclavicular region
time frame: 45 minutes cold exposure

Secondary Outcomes

Energy expenditure during cold exposure
time frame: 45 minutes cold exposure

Eligibility Criteria

Male participants from 21 years up to 35 years old.

Inclusion Criteria: - Male - Ethnic Chinese - Age between 21 to 35 years - Body Mass Index 18.5 to 22.9 - Normal resting blood pressure ~120/80 mmHg - Normal fasting blood glucose level <5.5 mmol/L Exclusion Criteria: - Do not train for or partake in competitive sports - Do not have any major diseases - Not on any prescribed medication

Additional Information

Official title BRown Fat Activity Measurement With Infrared imaginG tHermography and Thermogenesis - the BRIGHT Study
Description The recent rediscovery of functional brown adipose tissue (BAT) in healthy adults has opened up the exciting possibility of manipulating BAT for obesity management, and it is imperative to develop BAT imaging modalities that are non-invasive and safe for repeated use. Given that heat is a specific end-product of uncoupling protein-1 (UCP-1)-mediated BAT, this study examines whether surface body temperature assessed using infrared (IR) thermography can be a non-invasive measure to accurately and precisely predict brown adipose tissue (BAT) activation upon cold stimulation, which involves verifying an semi-automated method for characterizing thermal images. In addition, this study also aims to validate the use of a whole-body calorimeter to pick up changes in energy expenditure upon cold-induced thermogenesis. Lean, healthy male volunteers will be recruited. Thermal imaging of cervical-supraclavicular BAT will be done using an IR camera to assess changes in BAT activation. Blood samples will also be drawn at regular intervals to track changes in serum metabolites upon BAT activation. All in all, this study hopes to provide more supporting evidence that IR thermography is a viable imaging modality that is non-invasive, safe and reproducible of studying BAT activity.
Trial information was received from ClinicalTrials.gov and was last updated in June 2016.
Information provided to ClinicalTrials.gov by Clinical Nutrition Research Centre, Singapore.