This trial is active, not recruiting.

Condition female infertility due to nonimplantation of ovum
Treatments letrozole, clomiphene, hmg
Sponsor Navy General Hospital, Beijing
Start date May 2016
End date June 2019
Trial size 100 participants
Trial identifier NCT02775877, HL2015


The purpose of this study is to study the effects of letrozole and sequential clomiphene in ovulation and pregnancy in PCOS patients.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Allocation randomized
Endpoint classification safety/efficacy study
Intervention model parallel assignment
Masking single blind (subject)
Primary purpose treatment
Letrozole 5 mg tablet orally from 3-7 day of once a day menstrual cycle and clomiphene100 mg tablet orally once a day from 11-15 day of menstrual cycle.
(Active Comparator)
Letrozole 5 mg tablet orally from 3-7 day of once a day menstrual cycle and HMG 75u once a day by intramuscular injection from 11-15day of menstrual cycle

Primary Outcomes

live birth rate
time frame: 3 years

Secondary Outcomes

clinical pregnancy rate
time frame: 3 years
multiple pregnancies
time frame: 3 years
time frame: 3 years
mature follic
time frame: 1 month

Eligibility Criteria

Female participants from 20 years up to 38 years old.

Inclusion Criteria: - Women with PCOS Exclusion Criteria: - •Women more than 38 years or less than 20 years - With infectious diseases or endocrine diseases - Who refuse to participate in the experiment

Additional Information

Official title Letrozole and Sequential Clomiphene to Improve the Outcome of Embryo Transfer in Polycystic Ovary Syndrome (PCOS) Patients
Principal investigator Aiming Wang, Dr
Description To evaluate the efficacy of letrozole and clomiphene in PCOS patients is important,especially in resistent PCOS patients. Although most medications prove the effectiveness of letrozole and clomiphene,the subjects of letrozole and sequential clomiphene in PCOS patients are rarely.The trial may provide further basis for this medication in PCOS patients in ovulation. If the medication demonstrates efficacy, the method would help the patients with PCOS to deal with the problem of infertility.
Trial information was received from ClinicalTrials.gov and was last updated in May 2016.
Information provided to ClinicalTrials.gov by Navy General Hospital, Beijing.