Overview

This trial is active, not recruiting.

Condition long qt syndrome
Sponsor University of Copenhagen
Start date September 2010
End date May 2016
Trial size 50 participants
Trial identifier NCT02775513, LQTS

Summary

Loss-of-function mutations in voltage-gated potassium channels cause long QT syndrome (LQTS) due to a prolonged cardiac repolarisation phase. Hypoteses: patients with loss-of-function mutations also exhibit altered hormone release upon glucose ingestion.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Observational model case control
Time perspective cross-sectional
Arm
Patients with functional mutation in ion channels
Matched control

Primary Outcomes

Measure
glucose homeostasis
time frame: 6 hours

Secondary Outcomes

Measure
QT
time frame: 6 hours

Eligibility Criteria

Male or female participants at least 18 years old.

Inclusion Criteria: LQTS Gain of function Matched healthy controls Exclusion criteria:

Additional Information

Official title Metabolism of Patients With Genetically Caused Cardiac Arrhythmia
Description Loss-of-function mutations in voltage-gated potassium channels cause long QT syndrome (LQTS) due to a prolonged cardiac repolarisation phase. Voltage-gated potassium (Kv-) channels are known for their relation to malignant cardiac arrhythmias, but also play a role in pancreatic alpha- and beta cell hormone secretion, and possibly in incretin hormone secretion. We hypothesised that patients with loss-of-function mutations also exhibit altered hormone release upon glucose ingestion.
Trial information was received from ClinicalTrials.gov and was last updated in May 2016.
Information provided to ClinicalTrials.gov by University of Copenhagen.