fMRI Study of Effects of Nasal Insulin on Memory
This trial is active, not recruiting.
|Conditions||human memory, intranasal insulin|
|Treatments||intranasal insulin, intranasal saline|
|Sponsor||Virginia Polytechnic Institute and State University|
|Start date||December 2015|
|End date||April 2016|
|Trial size||45 participants|
|Trial identifier||NCT02758691, VT15-462|
Recent research has suggested insulin may be involved in how human's form and recall memories. This study is designed to look at how nasal insulin is used in the brain. Specifically, how insulin alters the various connections within brain regions that occur while adults perform simple attention and memory tasks. This study is divided into two parts: blood draw procedure and fMRI (functional Magnetic Resonance Imaging) procedure. The blood draw procedure is designed to look at the effects of intranasal insulin using a Precision Olfactory Delivery (POD) device on the blood levels of glucose and insulin. Those asked to participate will receiving a low-dose saline solution and low-dose of insulin through a nasal spray followed by a blood draw session to measure your blood glucose and insulin levels over a 90 minute period.
Participation in the fMRI (functional Magnetic Resonance Imaging) procedure will involve receiving a low-dose of insulin or a saline solution through a nasal spray using a Precision Olfactory Delivery (POD) device and brain scan using Magnetic Resonance Imaging (MRI). During the scan, participants will complete a series of memory tasks reflected on a computer screen. The trial will be randomized and double-blinded.
|Endpoint classification||safety/efficacy study|
|Intervention model||parallel assignment|
|Masking||double blind (subject, investigator)|
|Primary purpose||basic science|
Change in Memory Recall Performance during functional Magnetic Resonance Imaging task
time frame: 1 day
Male or female participants at least 18 years old.
Inclusion Criteria: - healthy adults over the age of 18 Exclusion Criteria: - any existing health conditions: including diabetes, history of alcoholism or drug dependence - contraindications to Magnetic Resonance Imaging (MRI): any non-titanium metal in the head or body
|Official title||Examining the Neural Correlates of Memory in Response to Intranasal Insulin Through fMRI & Device Testing|
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