Overview

This trial is active, not recruiting.

Conditions heart arrest, hypothermia, post cardiac arrest syndrome
Treatment cardiac arrest
Sponsor University of Aarhus
Start date October 2015
End date June 2016
Trial size 42 participants
Trial identifier NCT02733146, AU170878

Summary

To evaluate the significance of free-plasma deoxyribonucleic acid (DNA) and plasma histones in cardiac arrest patients.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Observational model cohort
Time perspective prospective
Arm
Patients who has suffered a cardiac arrest
cardiac arrest

Primary Outcomes

Measure
Plasma histones
time frame: Approximate 24 hours after cardiac arrest
Free-plasma DNA
time frame: Approximate 24 hours after cardiac arrest

Secondary Outcomes

Measure
Plasma histones
time frame: Approximate 48 hours and 72 hours after cardiac arrest
Free-plasma DNA
time frame: Approximate 48 hours and 72 hours after cardiac arrest

Eligibility Criteria

Male or female participants from 18 years up to 80 years old.

Inclusion Criteria: - Out of hospital cardiac arrest of presumed cardiac cause - Return of spontaneous circulation (ROSC) - Glasgow Coma Score < 8 - Age > 18 years and < 80 years Exclusion Criteria: - >60 minutes from the circulatory collapse to ROSC - Time interval > 4 hours from cardiac arrest to initiation of targeted temperature management - Terminal illness - Coagulation disorder - Unwitnessed asystolia - Cerebral performance category 3-4 before the cardiac arrest - Severe persistent cardiogenic shock - Pregnancy - Persistent cardiogenic shock (systolic blood pressure < 80 despite inotropic treatment) - New apoplexy or intracerebral hemorrhage - Lack of consent from the relatives - Lack of consent from the general practitioner - Lack of consent from the patient if he/she wakes up and is relevant

Additional Information

Official title Histones and Free-plasma DNA in the Days Following the Cardiac Arrest
Trial information was received from ClinicalTrials.gov and was last updated in April 2016.
Information provided to ClinicalTrials.gov by University of Aarhus.