Overview

This trial was last updated 5 days ago.
Condition cannabis dependence
Treatment fmri
Sponsor University of Electronic Science and Technology of China
Collaborator German Research Foundation
Start date July 2015
End date December 2016
Trial size 50 participants
Trial identifier NCT02711371, ART_Can_01

Summary

The aim of this functional magnetic resonance imaging (fMRI) study is to find out whether and how social and emotional brain function are altered in dependent cannabis users relative to healthy non-using control subjects after a 28 supervised abstinence period. Previous research in cannabis users has predominantly focused on cognitive functions. Moreover, studies have implicated that observed deficits in cannabis users may regenerate after a prolonged abstinence period. Findings might provide important information with respect to relapse vulnerability.

Recruiting in the following locations…

United States No locations recruiting
Other Countries Germany

Study Design

Observational model cohort
Time perspective cross-sectional
Arm
Cannabis dependent individuals according to DSM 4 criteria, aged 18-40 years
fmri
Healthy controls, socio-demographically matched
fmri

Primary Outcomes

Measure
fMRI neural activation patterns of social-emotional brain processes after 28 day abstinence
time frame: one timepoint = fMRI assessment after 28 day abstinence period

Secondary Outcomes

Measure
Ratings of subjective experience (pleasantness, rewarding value) will be assessed after 28 days of abstinence
time frame: one timepoint = during fMRI assessment after 28 day abstinence period
Relapse interview assessed with Timeline-Followback Method
time frame: one timepoint = 24 months post-fMRI-session

Eligibility Criteria

Male or female participants from 18 years up to 40 years old.

Inclusion Criteria: - Cannabis dependence according to DSM 4 criteria - 28 days of supervised abstinence Exclusion Criteria: - other DSM 4 diagnosis - neurological disorders

Additional Information

Official title Long-term Effects of Cannabis Use on Social and Emotional Brain Processes in Dependent Cannabis Users After a 28 Day Abstinence Period
Trial information was received from ClinicalTrials.gov and was last updated in November 2016.
Information provided to ClinicalTrials.gov by University of Electronic Science and Technology of China.