This trial is active, not recruiting.

Condition type 2 diabetes mellitus
Treatment alpha-linolenic acid
Sponsor St. Michael's Hospital, Toronto
Start date December 2012
End date March 2016
Trial size 200 participants
Trial identifier NCT02701894, ALA and GC in T2D


With the emerging worldwide epidemic of type 2 diabetes, dietary recommendations to improve diabetes management have been emphasized in the scientific community. Particular attention has been drawn to various benefits of replacing saturated fatty acids with unsaturated fatty acids. Alpha-linolenic acid, the only omega-3 fatty acid that is from plant sources, has been suggested by animal and cell studies to play a beneficial role in regulating blood glucose levels. However, human studies have been more inconsistent with their findings. The focus of this project is to investigate the evidence in the context of ALA and blood glucose parameters in participants with type 2 diabetes by conducting a systematic review and meta-analysis of randomized controlled trials.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Time perspective retrospective

Primary Outcomes

time frame: 1 month

Secondary Outcomes

time frame: 1 month
Fasting Blood Glucose
time frame: 1 month
Fasting Blood Insulin
time frame: 1 month
Glycated Albumin
time frame: 1 month
time frame: 1 month

Eligibility Criteria

Male or female participants of any age.

Inclusion Criteria: - Controlled, randomized, clinical trials - Trials greater than one month - Focusing on ALA and T2DM participants - Viable endpoint data Exclusion Criteria: - Non-human studies - Non-random treatment allocation - Less than 1 month - Lack of suitable control - Lack of endpoint data

Additional Information

Official title The Effect of Alpha-Linolenic Acid on Glycemic Control in Participants With Type 2 Diabetes
Principal investigator Vladimir Vuksan, PhD
Trial information was received from ClinicalTrials.gov and was last updated in March 2016.
Information provided to ClinicalTrials.gov by St. Michael's Hospital, Toronto.