This trial is active, not recruiting.

Conditions cognition, hydration
Treatment water
Sponsor Swansea University
Start date September 2015
End date March 2016
Trial size 130 participants
Trial identifier NCT02671149, HYD01


The aim of this study is to determine whether drinking plain water when mildly dehydrated benefits cognitive performance and mood. Volunteers undergo a dehydration protocol designed to result in minor dehydration. While some participants receive two 150ml drinks of water others do not. Differences in cognitive functioning are assessed.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Allocation randomized
Endpoint classification efficacy study
Intervention model parallel assignment
Masking single blind (subject)
Primary purpose prevention
Participants will receive two 150ml drinks of water during the dehydration protocol
Participants will receive two cups of 150ml plain water
(No Intervention)
Participants will drink nothing during the dehydration protocol

Primary Outcomes

Episodic memory - list of 30 words
time frame: change from 0 to 180 minutes after the start of the dehydration protocol
Focused attention - Eriksen Flanker Task
time frame: change from 0 to 180 minutes after the start of the dehydration protocol

Secondary Outcomes

Thirst (Participants rate their thirst)
time frame: change from 0 to 180 minutes after the start of the dehydration protocol

Eligibility Criteria

Male or female participants from 18 years up to 35 years old.

Inclusion Criteria: - In good general health i.e. no major health condition such as diabetes - BMI < 30 Exclusion Criteria: - Not on blood pressure medication or blood thinning medication such as aspirin - No learning difficulty such as dyslexia - Diabetes - Gastro-intestinal disease - High BMI - Cholesterol and BP - Smoker - Dyslexic/dyspraxic - Depression or history of depression or other psychiatric disorder

Additional Information

Official title How do Small Changes in Hydration Influence Cognition: A Mechanistic Investigation
Description As an essential nutrient, an inadequate intake of water has negative consequences: without a source of water death will occur in days. When Benton and Young (2015) reviewed the topic they concluded that in healthy adults, mild dehydration (in the range of a loss of 2% body mass) had been found to adversely influence mood and cognition. However, it is unclear at what degree of hypohydration these effects begin to emerge. This study was designed to determine whether small changes in hydration, of the level that might occur on a day to day basis, influence cognition and mood. During a dehydration protocol (sitting in a room heated to 30 degrees for four hours) young adult participants receive either drink two 150ml cups of water or nothing. Effects on memory, attention and mood are monitored.
Trial information was received from ClinicalTrials.gov and was last updated in February 2016.
Information provided to ClinicalTrials.gov by Swansea University.