Molecular Response After Concurrent Exercise With Low Glycogen
This trial is active, not recruiting.
|Treatment||standard meal containing low or high carbohydrate content|
|Start date||November 2015|
|End date||February 2016|
|Trial size||14 participants|
|Trial identifier||NCT02668445, NL54408.081.15|
This is a randomized, counterbalanced crossover design, in which 14 male subjects will complete two experimental trials. Each trial will be separated by a minimum of at least 12 days (range: 12-30 days). The study aims to investigate the effects of low glycogen availability on skeletal muscle molecular response after a concurrent exercise day.
|Intervention model||crossover assignment|
Subjects will eat a low carbohydrate diet
Subjects will eat a high carbohydrate diet
Proteins involved in hypertrophy
time frame: 10 hours
Male participants from 18 years up to 30 years old.
Inclusion Criteria: - Male gender between 18 and 30 years of age - BMI between 18.5 - 25 kg/m2 - Participating in regular exercise training (at least 1 exercise session, and a maximum of 3 exercise session per week) - Used to different types of exercise (endurance, resistance and/or concurrent) - Willing to give blood samples - Willing to give muscle biopsies - No use of antibiotics during the study or in the past month - No drug use - Suitable veins for blood withdrawal - Registered by a general-practitioner - Consumption of alcohol beverages is less than 21 per week - No blood donor during the study - No vegetarian and willing to eat meat during the experimental days - Able to be present and participate at both test days and pre testing moments - Not employed, or intern, or working on thesis at the department of Human Nutrition at Wageningen University - Not participating in another scientific study (except EetMeetWeet) - Able to participate during the experimental days en pre tests - Able to speak Dutch Exclusion Criteria: - Medical condition that can interfere with the study outcome (i.e. cardiovascular disease, pulmonary disease, gluten intolerance) - Systolic blood pressure >160 mmHg and/or diastolic blood pressure >100 mmHg - Use of medications known to interfere with gene expression in the muscles (i.e. statins, fenofibrate) - Use of antithrombotic therapy (marcoumar, sintromitis). - Diagnosed diabetes mellitus type 1 or 2 - (Chronic) injuries of the locomotor system that can interfere with the intervention
|Official title||The Effects of Glycogen Availability on the Skeletal Muscle Molecular Response After Concurrent Exercise|
|Description||Two experimental exercise trials; a low carbohydrate (= LOW) and a high carbohydrate (= HIGH) trial. During both experimental days subjects will complete an continues submaximal cycling bout in the morning followed by a resistance exercise session in the early afternoon. During the LOW trial subjects will receive a low carbohydrate mixed meal, during the HIGH trial subjects will be provided with a high carbohydrate meal. In addition, on both experimental days subjects will receive adequate protein beverages. Lastly, protein will be provided post resistance exercise.|
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