This trial is active, not recruiting.

Condition status post total hip and knee arthroplasty
Treatment effects of iv txa on teg in patients undergoing tha or tka
Sponsor West Virginia University
Start date December 2015
End date June 2016
Trial size 60 participants
Trial identifier NCT02648295, 1509851949


Blood management is an important part of successful total joint replacement. Loss of blood and transfusion can lead to poor outcomes for patients. The use of tranexamic acid (TXA) has become a standard component to many blood management programs. It is used to treat or prevent excessive blood loss during surgery and in various medical conditions such as excessive bleeding or hemorrhage. A normal body process prevents blood clots that occur naturally from growing and causing problems. When this process becomes overactive it can result in excessive bleeding, leading to increased blood transfusions. The proposed study seeks to evaluate the relationship between TXA and thromboelastogram (TEG) results.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Observational model case-only
Time perspective prospective

Primary Outcomes

All time measurements which indicate various aspects of clotting cascade
time frame: 3 months

Secondary Outcomes

Blood loss and transfusions
time frame: 3 months

Eligibility Criteria

Male or female participants from 40 years up to 90 years old.

Inclusion Criteria: - Primary total hip and knee arthroplasty patients presenting to WVU Center for Joint Replacement - 40-90 years old Exclusion Criteria: - Known coagulopathy - History of venothrombotic event - Unstable angina - Recent Myocardial infarction (MI) - History of bleeding events - History of chronic anemia - Preoperative anemia - Current use of blood thinners including aspirin

Additional Information

Official title Effects of IV Tranexamic Acid on the Thromboelastogram in Patients Undergoing Total Hip or Knee Arthroplasty
Trial information was received from ClinicalTrials.gov and was last updated in January 2016.
Information provided to ClinicalTrials.gov by West Virginia University.