Acute Effects of Different Macronutrient Compositions and Meal Distributions of the Food
This trial is active, not recruiting.
|Conditions||metabolic rate, plasma glucose, serum insulin, serum triglycerides, sense of satiety|
|Treatment||two test meals with two different macronutrient compositions|
|Sponsor||University Hospital, Linkoeping|
|Start date||September 2015|
|End date||September 2016|
|Trial size||28 participants|
|Trial identifier||NCT02622490, DIT2|
Thirty participants without serious concomitant diseases consume either a high- or a low carb. meal either as one single meal or as 5 small portions in the morning and are tested for effects on major cardiovascular risk markers and on metabolic rate for three hours on each occasion.
|Intervention model||crossover assignment|
|Primary purpose||basic science|
time frame: During about 3 hours
Effects on glucose and insulin
time frame: 3 hours
Male or female participants at least 18 years old.
Inclusion Criteria: - Healthy participants > 18 years with or without obesity Exclusion Criteria: - Major illnesses, - thyroid diseases, - need to take prednisolone, - psychiatric disease, - inability to understand Swedish
|Official title||Diet-induced Thermogenesis 2|
|Principal investigator||Fredrik H Nystrom, MD professor|
|Description||Thirty participants come to the metabolic ward at about 8 o´clock in the fasting state and stay until lunch on four occasions each. The participants are randomized to the order of the test meals. The meals have a total caloric content of 750 kcal and have either 50% of energy from carbohydrates (low fat) or 20% of energy from carbohydrates (low carb.). The meals are consumed on one occasion in the morning or divided in 5 portions (150 kcal each) for every 30 minutes, i.e. total combinations of meal composition and of meal distribution is 4. Effects of the food on p-glucose, s-insulin, blood-lipids, hormones and on metabolic rate is measured by blood tests or by indirect calorimetry (for metabolic rate). Sense of satiety is measured by visual analogue scales.|
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