Pituitary Function and Spontaneous Intracranial Hypotension
This trial is active, not recruiting.
|Conditions||hyperprolactinemia, spontaneous intracranial hypotension|
|Treatment||pituitary panel will be drawn pre-op and post-op for all patients.|
|Sponsor||Cedars-Sinai Medical Center|
|Start date||July 2015|
|End date||July 2017|
|Trial size||100 participants|
|Trial identifier||NCT02603549, Pro39357|
Previous research has identified spontaneous cerebral spinal fluid leakage as a cause for spontaneous intracranial hypotension, leading to positional headache patterns. Typical magnetic resonance imaging findings include subdural fluid collections, enhancement of pachymenginges, engorgement of venous structures, pituitary hyperemia, and sagging of the brain (SEEPS). Because pituitary hyperemia has been documented in cases of spontaneous cerebral spinal fluid leakage and is known to mimic a pituitary tumor or hyperplasia, we would like to like to assess the clinical manifestations and neuroimaging abnormalities of SIH patients with regard to the pituitary gland. Specifically, we are looking to analyze the compression of the pituitary stalk and conduct a systemic evaluation of pituitary function in SIH patients.
Comparing the levels of prolactin pre and post treatment
time frame: 90 days
Male or female participants at least 18 years old.
Inclusion Criteria: - Male or female patients - Age 18 years and older - Diagnosis of SIH: - LP - Brain MRI (SEEPS) Exclusion Criteria: - Pregnant and post-partum females - Nursing mothers - Patients with potential hyperprolactinemia due to: - Hypothyroidism, - Chronic renal disorder - Liver disease (including cirrhosis) - Primary or secondary amenorrhea - Polycystic Ovary Syndrome - Seizure disorder - Illicit drug use
|Official title||Spontaneous Spinal Cerebrospinal Fluid Leaks and Intracranial Hypotension|
|Principal investigator||Vivien Bonert, MD|
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