Interval-training and Appetite Regulation in Patients With Type 2 Diabetes
This trial is active, not recruiting.
|Condition||diabetes mellitus, type 2|
|Treatments||con, cw, iw|
|Start date||October 2015|
|End date||June 2016|
|Trial size||14 participants|
|Trial identifier||NCT02592616, H-15008542|
Four months of interval walking (IW) training results in substantial weight loss in opposition to energy-expenditure matched continuous walking (CW) training. The reason for this is unclear.
This study will assess if IW leads to greater exercise-induced suppression of appetite and ad libitum food intake compared to CW and no exercise.
Subjects with type 2 diabetes will be included in a crossover, counter-balanced, controlled study, where each subject will undergo three trials. Trials will be identical except the following interventions:
1. One hour of rest (CON)
2. One hour of interval walking (repeated cycles of 3 min of fast and 3 min of slow walking; IW)
3. One hour of continuous walking (CW) matched to IW with regards to energy-expenditure.
After the interventions subjects will undergo a liquid mixed meal tolerance test (450 kCal), with regular measurements of appetite-related hormones (insulin, ghrelin, Leptin, Cholecystokinin, PYY). Three hours into the mixed meal tolerance test, a standardised ad-libitum meal test will be served and intake will recorded. Free-living energy intake via food records will be assessed during the following 32 hours.
|Intervention model||crossover assignment|
Ad-libitum meal energy intake
time frame: Initiated 3 hours after the intervention
Free-living energy intake
time frame: For 32 hours following the ad-libitum meal.
time frame: Regularly during the 3 hours following the intervention
time frame: Regular assessments for 36 hours following the intervention
Male or female participants at least 30 years old.
Inclusion Criteria: - Type 2 Diabetes Mellitus - BMI > 25 Exclusion Criteria: - Pregnancy - Smoking - Contraindication to increased levels of physical activity - Eating disorder - Insulin dependence
|Official title||Interval-training and Appetite Regulation in Patients With Type 2 Diabetes|
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