Bioavailability and Absorption Kinetics of Phenolic Compounds and Specific Vitamins
This trial is active, not recruiting.
|Collaborator||Medical University of Graz|
|Start date||October 2015|
|End date||September 2016|
|Trial size||20 participants|
|Trial identifier||NCT02587468, 27-507 ex 14/15|
GOAL To identify absorption kinetics and bioavailability of phenolic compounds and specific vitamins from encapsulated Juice Plus+® powder
- Absorption kinetics of phenolic compounds in plasma
- Bioavailability of vitamins C, E, and carotenoids into plasma
Subjects: 20 healthy subjects from Graz region, meeting all inclusion criterions (see underneath).
|Endpoint classification||bio-availability study|
|Intervention model||single group assignment|
|Primary purpose||basic science|
Check of phenolic absorption between baseline and after 8wks of intake before-after comparison
Absorption kinetics of phenolic acids after 1, 2, 5 and 10 hours, measured via HPLC, evaluated by repeated measures ANOVA, and assessed via SPSS 19.0.
time frame: 1 year
Absorption of ß-carotene after 8 weeks of supplementation, measured via HPLC, evaluated by paired t-test, and assessed via SPSS 19.0
time frame: 1 year
Male or female participants from 20 years up to 50 years old.
Inclusion Criteria: - 20 healthy men and women, 20-50 years old; - non-smokers; - BMI >20 und <30 kg/m2; - no medication; - premenopausal; - normal dietary habits (no specific diets, meals, food components etc.); - adherence to wash-out period. Exclusion Criteria: - all people not meeting the inclusion criterions; - diet: subjects consuming >4 servings of fruits and vegetables per day; - subjects with any kind of food allergy or histamine intolerance; - highly trained subjects (> 5 training units/week); - women with menstrual dysfunctions; - pregnancy - alcoholics.
|Official title||Bioavailability and Absorption Kinetics of Phenolic Compounds and Specific Vitamins of a Commercially Available, Encapsulated Nutraceutical (Juice Plus+®)|
|Principal investigator||Manfred Lamprecht, PhD|
|Description||Phytonutrients are regarded to play an important role in many health-related issues like: - Improvement of redox balance - Anti-inflammatory effects - Prevention of chronic diseases like CVD, stroke, diabetes II, Alzheimer´s, AMD, and certain forms of cancer - Beneficial effects on human´s microbiome Therefore it is of scientific interest whether this product provides absorbable phytonutrients/phenolics and vitamins to support mechanistic explanations for the beneficial outcomes observed in the past after intake of Juice Plus+®. GOAL To identify absorption kinetics and bioavailability of phenolic compounds and specific vitamins from encapsulated Juice Plus+® powder MERITS - This study would reveal knowledge whether and to which extent specific vitamins and phenolic compounds are absorbed, including absorption kinetics/metabolism. - Data of this study may provide support for mechanistic arguments on the beneficial clinical outcomes observed and published in the past. ENDPOINTS - Absorption kinetics of phenolic compounds in plasma - Bioavailability of vitamins C, E, and carotenoids into plasma Absorption kinetics of phytonutrients: - Open-, one-arm study, absorption kinetics over 10 hours - 5 blood sample collections: baseline (= 0); 1hr, 2hrs, 5hrs and 10 hours after intake of 3 capsules - Wash-out of all food supplements and dietetic foodstuff: 2 weeks - Wash-out of phytonutrients: 48 hours before baseline sampling, accomplished via a phytonutrient-poor diet. Bioavailability of vitamins C, E, A and carotenoids: - Open-, one-arm study over 8 weeks - 2 blood sample collections: at baseline (2 weeks after the phenolics experiment) and after 8-weeks - Wash-out of all food supplements and dietetic foodstuff: 4 weeks, 2 weeks before the phenolics experiment + another 2 weeks Subjects: 20 healthy subjects from Graz region, meeting all inclusion criterions (see underneath).|
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