Reactivation of Varicella Zoster Virus and Risk of Vascular Disease
This trial is active, not recruiting.
|Conditions||varicella zoster, stroke, transient ischaemic attack, acute myocardial infarction|
|Sponsor||University College, London|
|Start date||June 2015|
|End date||December 2016|
|Trial size||2000 participants|
|Trial identifier||NCT02559596, 15/0311, F192|
The purpose of this study is to investigate whether there is an association between stroke or heart attack and reactivation of varicella zoster virus, measured by antibody levels, using linked data from the Health Survey for England and secondary care.
|Observational model||case control|
Odds ratio for the effect of high serum antibody titre on stroke or other vascular outcomes
time frame: Outcome assessed within 5 years of serum sample
Prevalence of age- and sex-specific serum VZV antibody titres as a marker for virus reactivation
time frame: Assessed at baseline recruitment to the HSE
Male or female participants at least 16 years old.
Inclusion Criteria: - Previous participant in the HSE between 2009 and 2013 with stored serum available. - Either a record of stroke or TIA or MI in linked HES data between 01/01/2009 and 31/12/2013 or selected as a matched control for those with a record of stroke/ TIA/MI in HES data. - Male or female, aged 16 years or above. Exclusion Criteria: - HSE participant with no stored serum sample
|Official title||Reactivation of Varicella Zoster Virus and Risk of Vascular Disease in the Health Survey for England: a Nested Case Control Study|
|Principal investigator||Charlotte Warren-Gash, MRCP PhD|
|Description||This study will use a case control design to investigate whether adult participants in the Health Survey for England between 2009 and 2013 who were admitted to hospital with either a stroke or heart attack had higher preceding levels of varicella zoster virus antibodies measured in stored serum samples compared to matched controls with no history of heart attack or stroke, controlling for a range of potential demographic, lifestyle and clinical confounders. This study is funded by the University College London Hospitals Biomedical Research Centre Fast Track grant scheme and has received ethics approval (ref 15/NW/0456).|
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