This trial is active, not recruiting.

Condition chronic hepatitis c
Sponsor Medical University of Graz
Start date January 2015
End date October 2017
Trial size 45 participants
Trial identifier NCT02545387, HCV-KM


Patients with hepatitis C show impaired neutrophil function. It is not known whether this is a direct of an indirect phenomenon. Using bone marrow biopsies from patients with hepatitis C it is possible to see whether neutrophil granulocyte progenitors are already infected with hepatitis C.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Observational model cohort
Time perspective retrospective

Primary Outcomes

viral RNA
time frame: day 1

Secondary Outcomes

neutrophil phagocytic capacity
time frame: day 1
hepatitis C virus proteins
time frame: day 1

Eligibility Criteria

Male or female participants from 18 years up to 99 years old.

Inclusion Criteria: - chronic hepatitis C - Genotype 1-4 Exclusion Criteria: - acute hepatitis C

Additional Information

Official title Hepatitis C Virus in Neutrophil Granulocyte Progenitor Cells
Principal investigator Vanessa Stadlbauer
Description Neutrophil granulocytes are important components of the innate immune system and pioneers in the fight against both fungal and bacterial infections. If pathogens enter the body, they are marked as foreign by antibodies and the complement system. Afterwards receptors on the neutrophils recognize and bind on these foreign substances to make them harmless. This process is called phagocytosis. Hepatitis C virus (HCV) and neutrophils are rarely associated. The HCV belongs to the Flaviviridae. It is a single-stranded, enveloped RNA virus with a positive polarity, which cause chronic hepatitis C (CHC) in approximately 170 million people worldwide. Subsequently, such an infection leads to liver cirrhosis and carcinoma in a significant proportion of patients. The virus infects mainly hepatocytes, but extrahepatic replication has also been shown. HCV usually enters the cell through receptor-mediated endocytosis (claudin-1, cluster of differentiation (CD)81, occludin and scavenger receptor 1), before it abuses the cell's own infrastructure for the viral protein synthesis. The aim of this study is to determine neutrophil function in chronic hepatitis C infected patients. Furthermore the investigators want to examine if neutrophils or their precursor cells are infected with HCV and if this leads to their dysfunction.
Trial information was received from ClinicalTrials.gov and was last updated in November 2016.
Information provided to ClinicalTrials.gov by Medical University of Graz.