Overview

This trial is active, not recruiting.

Condition creatinine clearance quantitative trait locus
Sponsor National Taiwan University Hospital
Start date September 2015
End date July 2016
Trial size 500 participants
Trial identifier NCT02541981, 201507087RIND

Summary

The outcome of heart transplantation has improved by years. The renal dysfunction is a major complication after heart transplantation.The natural course of renal function following orthotopic heart transplant is not clear in Taiwan. A retrospective study was conducted on patients who received a heart transplant at National Taiwan University Hospital between 1987 and 2015.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Observational model case-only
Time perspective retrospective

Primary Outcomes

Measure
Natural course for renal function (ex blood creatine leveal ,eGFR) after heart transplantation
time frame: patients who received a first heart transplant at the NTUH(Taiwan) between 1987 and 2015

Eligibility Criteria

Male or female participants from 18 years up to 80 years old.

This study included patients with a first HTx performed at NTUH between1987 and 2015. Patients were excluded if their first HTx was a combined transplant involving a KTx, they had renal replacement therapy prior to their HTx.

Additional Information

Official title Natural Course for Renal Function After Heart Transplantation
Principal investigator Chen Cheryl Chia-Hui, PHD
Description The investigators conducted a retrospective cohort study of patients who received a first heart transplant at the NTUH(Taiwan) between 1987 and 2015 . Clinical data were obtained and a retrospective chart review, and were collected up to 10 years . Data was collected from medical records and the heart transplant electronic database including: demographic parameters such as age and gender; etiology of heart failure; the presence of any of the following comorbidities: history of smoking, diabetes, hypertension, peripheral vascular disease and previous sternotomy; pre-transplant cholesterol levels; the use of any of the following pretransplant hemodynamic support measures:intravenous inotropes, intra-aortic balloon pump and ventricular assist device;creatinine levels; listing status according to the UNOS classification; waiting time; heart ischemic time;immunosuppression drug levels(cyclosporine,prograft or certican) and development of end stage renal disease requiring onset of dialysis therapy. Creatinine levels and GFRwere collected before transplantation and then the closest level to every month after heart transplant. The clinical outcomes of interest analyzed in this study included the development of post-transplant end stage renal disease and death.
Trial information was received from ClinicalTrials.gov and was last updated in September 2015.
Information provided to ClinicalTrials.gov by National Taiwan University Hospital.