Non Invasive Optical Imaging of WBC Count
|Sponsor||Massachusetts General Hospital|
|Start date||September 2015|
|End date||July 2017|
|Trial size||35 participants|
|Trial identifier||NCT02512666, 15-070|
This research study is looking at a small device that measures white blood cell (WBC) counts by being placed against the finger nail for participants who are undergoing stem cell transplantation at Massachusetts General Hospital or have a hematologic malignancy and are being seen as an outpatient.
|Intervention model||single group assignment|
Video of nail-fold imaging captured by capillaroscope
time frame: 4 weeks
All participants at least 18 years old.
Inclusion Criteria: - Patients with lymphoid malignancies or plasma cell dyscrasias who are admitted to the Massachusetts General Hospital to undergo autologous stem cell transplantation or are seen in the outpatient clinic - Age ≥ 18 years - Ability to understand and the willingness to sign a written informed consent document. - Patients must have WBC ≥ 3000 / µl and ANC ≥ 1500 / µl at admission or their last clinical visit to be enrolled. Exclusion Criteria: - History of allergic reactions attributed to compounds of similar chemical or biologic composition of baby oil. - Myelodysplasia - Skin photoype < 4 in the Fitzpatrick scale.
|Official title||Non Invasive Optical Imaging of Capillaries Through the Nailfold for White Blood Cell Enumeration in Patients With Hematologic Malignancies|
|Principal investigator||Yi-Bin A Chen, MD|
|Description||The objective of this study is to obtain data that would support the use of a method to obtain WBC counts from images of small blood vessels called capillaries. These would be obtained by pressing a small device on the surface of participants' finger nails to look through the nail. These images will be obtained using a portable microscope called the Dino-Lite Digital Microscope. Having a non-invasive way to quickly measure WBC counts could be useful for a variety of healthcare applications.|
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