Condition acute lung injury
Treatments oxygen, xenon
Sponsor Beijing Anzhen Hospital
Start date January 2015
End date July 2017
Trial size 160 participants
Trial identifier NCT02468531, 2014.7-2017.7


Acute lung injury (ALI) is the vital complication of Stanford type A aortic dissection. It is confirmed that Xenon has the significant protective effect on important organs and has no suppression on the cardiovascular system. Furthermore, our earlier trial has already clarified that static inflation with 50% Xenon during cardiopulmonary bypass could attenuate ALI for Standford A acute aortic dissection. However the protection effect was restricted for the limited time. Aimed to enhance the protection effect of Xenon, we designed this randomized trial that anesthesia with 50% xenon one hour before and after CPB and pulmonary static Inflation with 50%,75% and 100% Xenon during CPB respectively.

Recruiting in the following locations…

United States No locations recruiting
Other Countries China

Study Design

Allocation randomized
Endpoint classification safety/efficacy study
Intervention model parallel assignment
Masking double blind (subject, caregiver, investigator, outcomes assessor)
Primary purpose treatment
50% oxygen inhalation one hour before and after CPB,and Pulmonary Static Inflation with 50% oxygen during CPB.
50% oxygen inhalation
50% oxygen inhalation one hour before and after CPB,and Pulmonary Static Inflation with 50%,75% and 100% Xenon during CPB respectively.
50% Xenon inhalation

Primary Outcomes

oxygenation index
time frame: perioperative period
extubation time
time frame: perioperative period
complications of vital organs
time frame: perioperative period
early mortality
time frame: 30 days after surgery

Secondary Outcomes

alterations in cytokine and ROS in the perioperative period
time frame: perioperative period

Eligibility Criteria

Male or female participants from 18 years up to 65 years old.

Inclusion Criteria: - diagnosed with acute Stanford type A aortic dissection within 2 weeks according to the diagnosis and treatment guidelines for thoracic aortic disease by ACC/AHA in 2010 (Circulation, 2010), - ≥18y, - Willing to sign the informed consent Exclusion Criteria: - A history of cardiopulmonary diseases, - A history of nervous system diseases, - A history of hematological system diseases, - A history of liver and renal diseases, - A history of thrombotic diseases, - Infection, - Refused sign the informed consent.

Additional Information

Official title The Clinic Trial On Protection Of Xenon Anaesthesia Against Perioperative Acute Lung Injury For Standford A Acute Aortic Dissection
Principal investigator Weiping Weiping
Trial information was received from ClinicalTrials.gov and was last updated in October 2016.
Information provided to ClinicalTrials.gov by Beijing Anzhen Hospital.