Gene Expression Profiles in Chronic Periodontitis
This trial is active, not recruiting.
|Treatment||genom-based whole-genome transcriptomic|
|Start date||February 2013|
|End date||August 2015|
|Trial size||46 participants|
|Trial identifier||NCT02467283, KOU KAEK 2013 / 15|
Current concepts of the causes of periodontitis implicate a bacterial infection as the primary cause of the disease. Several bacterial species residing in a biofilm on tooth surfaces are closely associated with periodontitis. Chronic periodontitis (CP) is initiated and sustained by bacterial plaque, but host defense mechanisms play an integral role in its pathogenesis.
Gene expression profiling is a powerful means of generating comprehensive genome-level data sets on diseases such as cancer, asthma, rheumatoid disorders and periodontitis, and provides significant insight information for these diseases. Gene expression profiling may provide an evidence for involving genes in the pathogenesis of CP and generate further information other than clinical signs and symptoms of CP.
The aim of this study was to identify gene-expression patterns of patients with chronic periodontitis by whole-transcriptome gene-expression analyses.
|Observational model||case control|
time frame: 2 months
Gen networking map
time frame: 2 months
Male or female participants at least 18 years old.
Inclusion Criteria: 1. CP patients had at least 20 teeth exhibiting >30% of measured sites with >5mm clinical attachment loss. 2. Had bleeding on probing (BOP) at >50% of the proximal sites. Exclusion Criteria: 1. Had any known systemic diseases that can influence the periodontal status, oral diseases other than chronic periodontitis and ongoing orthodontic therapy. 2. History of hepatitis, HIV infection, or diabetes; requirement for antibiotic prophylaxis, pregnancy or lactation; and long-term use of anti-inflammatory drugs. 3. Should be free of systemic diseases 4. Individuals had to be older than 18 years of age.
|Official title||Gene Expression Profiles in Chronic Periodontitis: A Gene Network-based Microarray Analysis|
|Principal investigator||Esra Guzeldemir-Akcakanat, DDS, PhD|
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