Overview

This trial is active, not recruiting.

Condition chronic periodontitis
Treatment genom-based whole-genome transcriptomic
Sponsor Kocaeli University
Start date February 2013
End date August 2015
Trial size 46 participants
Trial identifier NCT02467283, KOU KAEK 2013 / 15

Summary

Current concepts of the causes of periodontitis implicate a bacterial infection as the primary cause of the disease. Several bacterial species residing in a biofilm on tooth surfaces are closely associated with periodontitis. Chronic periodontitis (CP) is initiated and sustained by bacterial plaque, but host defense mechanisms play an integral role in its pathogenesis.

Gene expression profiling is a powerful means of generating comprehensive genome-level data sets on diseases such as cancer, asthma, rheumatoid disorders and periodontitis, and provides significant insight information for these diseases. Gene expression profiling may provide an evidence for involving genes in the pathogenesis of CP and generate further information other than clinical signs and symptoms of CP.

The aim of this study was to identify gene-expression patterns of patients with chronic periodontitis by whole-transcriptome gene-expression analyses.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Observational model case control
Time perspective cross-sectional
Arm
All subjects were free of systemic diseases and to be included, individuals had to be older than 18 years of age. Chronic periodontitis was diagnosed according to American Academy of Periodontology 1999 Consensus Report.
genom-based whole-genome transcriptomic
Gene expression profiling is a powerful means of generating comprehensive genome-level data sets.
Control subjects had no radiographic evidence of bone loss or any sign of past and present periodontitis. All subjects were free of systemic diseases and to be included, individuals had to be older than 18 years of age.
genom-based whole-genome transcriptomic
Gene expression profiling is a powerful means of generating comprehensive genome-level data sets.

Primary Outcomes

Measure
mRNA quantification
time frame: 2 months

Secondary Outcomes

Measure
Gen networking map
time frame: 2 months

Eligibility Criteria

Male or female participants at least 18 years old.

Inclusion Criteria: 1. CP patients had at least 20 teeth exhibiting >30% of measured sites with >5mm clinical attachment loss. 2. Had bleeding on probing (BOP) at >50% of the proximal sites. Exclusion Criteria: 1. Had any known systemic diseases that can influence the periodontal status, oral diseases other than chronic periodontitis and ongoing orthodontic therapy. 2. History of hepatitis, HIV infection, or diabetes; requirement for antibiotic prophylaxis, pregnancy or lactation; and long-term use of anti-inflammatory drugs. 3. Should be free of systemic diseases 4. Individuals had to be older than 18 years of age.

Additional Information

Official title Gene Expression Profiles in Chronic Periodontitis: A Gene Network-based Microarray Analysis
Principal investigator Esra Guzeldemir-Akcakanat, DDS, PhD
Trial information was received from ClinicalTrials.gov and was last updated in August 2016.
Information provided to ClinicalTrials.gov by Kocaeli University.