Chronic Periodontitis and Tooth Loss in Patients With Rheumatoid Arthritis
This trial is active, not recruiting.
|Conditions||periodontitis, rheumatoid arthritis|
|Sponsor||University of Birmingham|
|Collaborator||Dudley Group NHS Foundation Trust|
|Start date||November 2010|
|End date||November 2012|
|Trial size||400 participants|
|Trial identifier||NCT02441920, RG_09-196|
Periodontitis is a highly prevalent chronic inflammatory disease that is characterized by loss of the periodontal ligament and alveolar bone, and is a major cause of tooth loss. Results from clinical and epidemiological studies have suggested that periodontitis and tooth loss are more prevalent in individuals with rheumatoid arthritis (RA). There is evidence to suggest that periodontitis could indeed be a causal factor in the initiation and maintenance of the autoimmune inflammatory response that occurs in RA. If so, chronic periodontitis might represent an important modifiable risk factor for RA. However, to date longitudinal studies on the effect of periodontitis on disease progression in RA are lacking. The aim of the present study is to assess the periodontal status of patients enrolled in an established longitudinal cohort of RA patients. These data will then be analysed to evaluate whether or not periodontal inflammation is related to parameters of rheumatoid arthritis.
The inception cohort of 400 patients will be followed up for 20 years following recruitment.
Associations between periodontal parameters and RA related factors including disease activity, severity, progression, and comorbidities
time frame: 1 year
Male or female participants at least 18 years old.
Inclusion Criteria: - Fulfilling the 1987 revised criteria for the classification of Rheumatoid arthritis - Under active follow−up by a rheumatologist at the Dudley Group of Hospitals - Participation in study 04/Q2702/18 "Establishment of an inception cohort for the prospective evaluation of predictors of cardiovascular morbidity and mortality in patients with rheumatoid arthritis". - Participation in study 04/Q2702/18 "A prospective study of micro and macro vascular disease in a cohort of patients with Rheumatoid arthritis"). - Written informed consent Exclusion Criteria: - No absolute exclusion criteria
|Official title||Chronic Periodontitis and Tooth Loss in Patients With Rheumatoid Arthritis|
|Principal investigator||Paola de Pablo|
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