Overview

This trial has been completed.

Conditions aging, muscle strength
Treatment resistance training
Sponsor University of Jyvaskyla
Start date January 2015
End date December 2015
Trial size 105 participants
Trial identifier NCT02413112, OKM/70/626/2014

Summary

It is well accepted that physical activity in the form of resistance training produces a wide variety of neuromuscular-skeletal and health benefits. It is recommended in Finland that older individuals (over 65yr) should perform resistance training twice per week.

Unfortunately, only approx. 5% of older individuals fulfill this recommendation. As Finnish society grows ever older, research should focus on the specific needs of this group and how to improve participation in physical activity, which may ultimately lead to modification of physical activity recommendations - resistance training recommendations are currently the same for young and older adults and do not include specific recommendations on the type of resistance training. However, these recommendations appear to have been developed for "best possible" improvements in maximum strength and muscle size.

Therefore, it is of great importance to identify the number of resistance training sessions per week required to induce improvements in physical fitness, metabolic and bone health status, and importantly the reasons for adherence to/drop-out of resistance training interventions (e.g. motivation to train) in a multi-discipline study. This knowledge would benefit policy makers to update current recommendations for resistance training and to devise strategies to advise realistic targets for resistance training in the older, particularly the less-educated, age group (e.g. TELI-strategy for 2020).

The present study will include a 12-month resistance training intervention with a 12-month follow-up period. Interviews and questionnaires will assess psychological/sociological data and will be collected from both drop-out subjects and those that complete the intervention. Neuromuscular performance and functional capacity will be tested using conventional methods, along with body composition, bone density, and blood tests for metabolic markers of health. Diet and other physical activity will be controlled throughout the intervention period. Measurements are to be performed every 3 months.

It is expected that 5 international peer-reviewed articles will be published in 2016-2017. The data will be presented at international and national conferences in 2015-2017. Finally, results of the entire research will be published in national peer-reviewed journals (e.g. The Age Institute's "Raportteja"). All subjects will be invited to attend an information meeting where group results will be presented and explained.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Allocation randomized
Intervention model parallel assignment
Masking open label
Primary purpose basic science
Arm
(Experimental)
Subjects train once per week in the University gym. All training sessions are supervised by the researchers.
resistance training
Whole-body resistance training in the University gym that is supervised by researchers. Training once per week, Training twice per week, Training thrice per week.
(Experimental)
Subjects train twice per week in the University gym. All training sessions are supervised by the researchers.
resistance training
Whole-body resistance training in the University gym that is supervised by researchers. Training once per week, Training twice per week, Training thrice per week.
(Experimental)
Subjects train three times per week in the University gym. All training sessions are supervised by the researchers.
resistance training
Whole-body resistance training in the University gym that is supervised by researchers. Training once per week, Training twice per week, Training thrice per week.
(No Intervention)
Subjects continue with their normal daily lives, just performing measurements

Primary Outcomes

Measure
Force production (Isometric and dynamic maximum strength tests of lower limbs)
time frame: Change from baseline at 3, 9 and 15 months with data presented at 24 months post-initiation
Muscle hypertrophy (Cross-sectional area of quadriceps and triceps surae muscles)
time frame: Change from baseline at 3, 9 and 15 months with data presented at 24 months post-initiation

Secondary Outcomes

Measure
Body composition (DXA scanning)
time frame: Change from baseline at 3, 9 and 15 months with data presented at 24 months post-initiation
Blood count
time frame: Change from baseline at 3, 9 and 15 months with data presented at 24 months post-initiation
Oral glucose tolerance test
time frame: Change from baseline at 3, 9 and 15 months with data presented at 24 months post-initiation
Basal hormone concentrations
time frame: Change from baseline at 3, 9 and 15 months with data presented at 24 months post-initiation

Eligibility Criteria

Male or female participants from 65 years up to 75 years old.

Inclusion Criteria: - BMI<37 - Does not smoke - Able to perform all tests and exercises - Free from episodes during physical activity Exclusion Criteria: - BMI>37 - Use of waling aids - Previous testosterone-altering treatment, e.g. in cancer treatment or hypogonadism - Serious cardiovascular disease that may lead to complications during exercise - Use of pharmaceuticals that affect neuromuscular or endocrine systems - Regular endurance training>3hr per week - Resistance training experience

Additional Information

Official title Minimum Resistance Training Frequency: Effect on Motivation and Adherence to Train, Overall Health Status and Neuromuscular Performance
Principal investigator Simon Walker, Ph.D
Trial information was received from ClinicalTrials.gov and was last updated in October 2016.
Information provided to ClinicalTrials.gov by University of Jyvaskyla.