This trial is active, not recruiting.

Condition heart failure
Treatments high-intensity interval exercise training, combined exercise training
Sponsor University of Athens
Start date May 2010
End date June 2015
Trial size 30 participants
Trial identifier NCT02387411, not applied


Chronic heart failure (CHF) is a clinical syndrome presented with central, cardiac deterioration as well as peripheral vascular and muscular abnormalities, resulting finally to reduced exercise tolerance, quality of life and mortality rates. Exercise training is a major component of rehabilitation / secondary prevention interventions, inducing significant beneficial changes in mechanisms of pathophysiology, exercise tolerance, functional capacity and quality of life, while a positive impact on hospitalization and mortality reduction should not be also excluded. There has been growing interest in the characteristics and modalities of exercise training able to induce optimal benefits. High intensity and interval mode have been shown to induce greater benefits than moderate intensity and continuous mode regimes. Additionally, there has been sound rationale for the inclusion of strength training, which has been also shown able to yield benefits in terms of exercise capacity and quality of life. However, there haven't been much data on the so called combined regimes, which include both aerobic exercise and strength training. This study aims at investigating the effects of combined high-intensity interval and strength training compared to high-intensity interval exercise alone in CHF.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Allocation randomized
Endpoint classification efficacy study
Intervention model parallel assignment
Masking open label
Primary purpose treatment
(Active Comparator)
high-intensity interval exercise training
high-intensity interval exercise training
High-intensity interval exercise training [4 reps * (4 min at 80% VO2peak + 3 min at 50% VO2peak)]
(Active Comparator)
combined exercise training
combined exercise training
High intensity [2 reps * (4 min at 80% VO2peak + 3 min at 50% VO2peak)] and strength exercise training (2-4 sets, 10-12 reps, 60-65% 1RM, for quadriceps and hamstrings, 14 min in total)

Primary Outcomes

aerobic exercise capacity (assessed by cardiopulmonary exercise testing)
time frame: 3 months

Secondary Outcomes

strength exercise capacity (assessed by 1-repetition maximum test)
time frame: 3 months
quality of life (assessed by MLWHF questionnaire)
time frame: 3 months
quadriceps local adaptations (assessed by muscle biopsies)
time frame: 3 months
quadriceps cross sectional area (assessed by CT)
time frame: 3 months

Eligibility Criteria

Male or female participants from 18 years up to 80 years old.

Inclusion Criteria: - stable heart failure - ejection fraction <=45% - optimal medical treatment - NYHA class <=III Exclusion Criteria: - contraindications for maximal cardiopulmonary exercise testing (CPET) - moderate to severe COPD - inability to follow exercise programs due to orthopaedic problems

Additional Information

Official title High-intensity Interval Versus Combined High-intensity Interval and Strength Exercise Training in Chronic Heart Failure
Trial information was received from ClinicalTrials.gov and was last updated in March 2015.
Information provided to ClinicalTrials.gov by University of Athens.