Overview

This trial is active, not recruiting.

Condition cushing disease
Sponsor Vastra Gotaland Region
Start date September 2013
End date September 2016
Trial size 400 participants
Trial identifier NCT02350153, NSSCDIO

Summary

The purpose of this study is to study since 1987 all patients diagnosed with CD in Sweden and determine their outcomes including mortality. A secondary objective is to focus on patients in remission and identify determinants of their different outcomes.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Observational model cohort
Time perspective retrospective
Arm

Primary Outcomes

Measure
Mortality
time frame: From date of diagnosis until the last day of December 2014 or date of death from any cause, whichever came first, assessed up to 20 years.

Secondary Outcomes

Measure
influence of Cushing's Disease on myocardial infarction
time frame: From date of diagnosis until the last day of December 2014 or date of death from any cause, whichever came first, assessed up to 20 years
influence of Cushing's Disease on stroke
time frame: From date of diagnosis until the last day of December 2014 or date of death from any cause, whichever came first, assessed up to 20 years
influence of Cushing's Disease on cancer
time frame: From date of diagnosis until the last day of December 2014 or date of death from any cause, whichever came first, assessed up to 20 years
influence of Cushing's Disease on hip fracture risk
time frame: From date of diagnosis until the last day of December 2014 or date of death from any cause, whichever came first, assessed up to 20 years
incidence of Cushing's Disease in Sweden
time frame: Assessed up to 20 years.
prevalence of Cushing's Disease in Sweden
time frame: Assessed up to 20 years.

Eligibility Criteria

Male or female participants at least 18 years old.

Inclusion Criteria: - All patients registered with Cushing's Disease in Sweden since 1987 in the statistical database for in- and out-patients, at the Swedish National Board of Health and Welfare will be included in the study. Exclusion Criteria:

Additional Information

Official title National Swedish Study in Cushing´s Disease Incidence and Outcomes
Principal investigator Gudmundur Johannsson, Professor
Description This study is a retrospective nationwide study of all patients in Sweden with diagnosis CD between 1987 and 2013 were baseline data at diagnosis, information about the different treatments and follow-up data is going to be obtained by reviewing patients' medical journals. This information as well as the exact diagnose criteria for each patient are going to be extracted by Endocrinologists in all University Hospitals in Sweden. An expert group at the Sahlgrenska University Hospital in Gothenburg will put together the data.By the use of the Swedish Personal Number, the investigators are going to obtain information about both patients' and background population co-morbidities which have been collected in the different Swedish Registers. Primary aim: To study mortality of CD in Sweden. Secondary aims: 1. To study the influence of CD on myocardial infarction 2. To study the influence of CD on stroke 3. To study the influence of CD on cancer 4. To study the influence of CD on hip fracture risk 5. To study incidence and prevalence of CD in Sweden.
Trial information was received from ClinicalTrials.gov and was last updated in January 2016.
Information provided to ClinicalTrials.gov by Vastra Gotaland Region.