Overview

This trial is active, not recruiting.

Condition esophageal neoplasms
Treatment insufflation of carbon dioxide (co2)
Sponsor Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Start date December 2014
End date September 2016
Trial size 20 participants
Trial identifier NCT02330536, QMao

Summary

Video-assisted thoracoscopic surgery (VATS) has become a standard technique for addressing all types of thoracic pathology. Insufflation of carbon dioxide (CO2) into the operated chest cavity could increase lung collapse and improve surgical field view. The actual thoracic pressure values may not be identical with the presetting on the insufflator display. This overshoot pressure during VATS may compromise cardiac and pulmonary function. The purpose of this study is to evaluate the effects of intrathoracic pressure overshoot during two-lung ventilation on the hemodynamic and respiratory function and clarify the relative safety of two different techniques of insufflation.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Allocation randomized
Endpoint classification safety/efficacy study
Intervention model crossover assignment
Masking double blind (caregiver, outcomes assessor)
Primary purpose prevention
Arm
(Experimental)
insufflation of carbon dioxide at 8L/min
insufflation of carbon dioxide (co2)
After patients were positioned, CO2 was insufflated into right pleural cavity at eight or sixteen L/min. during video-assisted thoracoscopic surgery, thoracic pressure, hemodynamic and respiratory parameters were recorded.
(Experimental)
insufflation of carbon dioxide at 16L/min
insufflation of carbon dioxide (co2)
After patients were positioned, CO2 was insufflated into right pleural cavity at eight or sixteen L/min. during video-assisted thoracoscopic surgery, thoracic pressure, hemodynamic and respiratory parameters were recorded.

Primary Outcomes

Measure
thoracic pressure overshoot
time frame: one hour during CO2 insufflation
Hemodynamic change
time frame: one hour during CO2 insufflation
Respiratory change
time frame: one hour during CO2 insufflation

Eligibility Criteria

Male or female participants from 20 years up to 70 years old.

Inclusion Criteria: - American Society of Anesthesiologists (ASA) Physical Status Ⅰ,Ⅱ - Patients with esophageal carcinoma - Elective video-assisted thoracic surgery Exclusion Criteria: - Allergic to drugs used in the study - Refusal of VAST - Arrhythmia or treated with antiarrhythmic drug

Additional Information

Official title Cardiopulmonary Effects of Intrathoracic Pressure Overshoot During Carbon Dioxide Insufflation in Thoracoscopic Surgery
Trial information was received from ClinicalTrials.gov and was last updated in January 2015.
Information provided to ClinicalTrials.gov by Daping Hospital and the Research Institute of Surgery of the Third Military Medical University.