Effect of Probiotics on Chronic Periodontitis in Smoker and Non- Smokers
This trial has been completed.
|Treatment||lactobacillus brevis cd2 lozenges|
|Sponsor||Next Gen Pharma India Pvt. Ltd.|
|Collaborator||Krishnadevaraya College of Dental Sciences & Hospital|
|Start date||February 2015|
|End date||November 2016|
|Trial size||60 participants|
|Trial identifier||NCT02329353, BAN_PERIO-SOM_01|
Periodontitis is one of the most common chronic inflammatory disease with the etiology of bacterial plaque and is associated with a number of putative bacterial species. The periodontal destruction is substantially mediated by the host, driven by the bacterial challenge. The presence of pathogenic bacteria with the absence of so-called "beneficial bacteria" and the susceptibility of the host are the main aetiological factors of periodontal diseases.
|Endpoint classification||safety/efficacy study|
|Intervention model||parallel assignment|
Improvement in Clinical Periodontal Indices
time frame: 8 weeks
Change in microbiological indices
time frame: 8 weeks
Male or female participants from 30 years up to 55 years old.
Inclusion Criteria: - Patients free from any systemic illness - Previously untreated moderate to severe generalised chronic periodontitis. - Patients free from adverse reactions to lactose or fermented milk products - Patient unwilling to quit smoking and smokers over the past one year ( Smoker arm). Exclusion Criteria: - Previous history of antibiotic usage over past 6 months - Patients who are eligible for antibiotic usage during the treatment course - Patients who are pregnant, lactating, alcoholic or who had undergone any surgical or nonsurgical therapy within 6 months. - Acute oral lesions or necrotising ulcerative periodontitis
|Official title||Clinical And Microbiological Analysis Of Orally Administered Lactobacillus Probiotic Lozenges In Chronic Periodontitis Patients Among Smokers And Non-smokers And Its Correlation With Clinical Parameters - A Clinico-Microbiological Study|
|Principal investigator||Rudrakshi chickanna, MDS|
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