Overview

This trial is active, not recruiting.

Condition lung cancer
Treatments desflurane, propofol
Sponsor Juntendo University
Collaborator Baxter Healthcare Corporation
Start date October 2012
End date June 2016
Trial size 80 participants
Trial identifier NCT02324283, 12-97

Summary

Which is more adequate general anesthetic agent, desflurane or propofol, for emergence and recovery time, and perioperative oxygenation in lung resection surgery?

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Allocation randomized
Endpoint classification efficacy study
Intervention model parallel assignment
Masking single blind (subject)
Arm
(Active Comparator)
Desflurane group: this group of patients receives desflurane as the main anesthetic agent in addition to remifentanil infusion at 0.1~0.3 mcg/kg/min during one-lung anesthesia. Bispectral index will be maintained between 45 and 50. Arterial blood gases and pulmonary blood flow by using tansesphageal echocardiogrphy will be measured.
desflurane Suprene
Desflurane group: this group of patients receives desflurane as the main anesthetic agent during one-lung anesthesia. Propofol group: this group of patients receives propofol as the main anesthetic agnet during on-lung anesthesia.
(Active Comparator)
Propofol group: this group of patients receives propofol as the main anesthetic agent in addition to remifentanil infusion at the rate of 0.1~0.3 mcg./g/min during one-lung anesthesia. Bispectral index will be maintained between 45 and 50. Arterial blood gases and pulmonary blood flow by using tansesphageal echocardiogrphy will be measured.
propofol Diprivan
Propofol group:this group of patients receives propofol as the main anesthetic agent during one-lung anesthesia.

Primary Outcomes

Measure
oxygenation
time frame: prior to surgery to one-hour after extubation

Secondary Outcomes

Measure
rapidity of emergence from anesthesia
time frame: one minute after cessation of anethetic agents to one hour after extubation
quality of consiousness
time frame: after extubation
postoperative nausea and vomiting
time frame: on the postoperative day 1

Eligibility Criteria

Male or female participants from 20 years up to 75 years old.

Inclusion Criteria: - Patients agree to participate in the study - Patients undergoing lung cancer surgery requiring one-lung ventilation. - American Society of Anesthesiologists Physical Status Class 1 or 2 Exclusion Criteria: - Patients with any of the following will be excluded from lung cancer patients. - New York Heart Association Classification more than 2 - Respiratory dysfunction Vital Capacity or percent predicted Forced expiratory volume in one second is less than 50 % - Pulmonary hypertension with mean pulmonary arterial pressure more than 30 mmHg - Coagulation dysfunction - The administration of steroids and immunosuppressive agents within 3 months prior to surgery - Infection with active inflammation - Pneumonectomy patients - Cases of epidural anesthesia is contraindicated

Additional Information

Official title Comparison of Emergence and Recovery Time, and Evaluation of Oxygenation During One-lung Ventilation With Desflurane and Propofol Anesthesia in Lung Surgery- A Pilot Study
Principal investigator Eiichi Inada, M.D.
Description The investigators plan to investigate the effects of desflurane on oxygenation (prevention of HPV) of OLV compare with propofol which is used in general anesthesia for lung resection. Transesophageal echocardiography (TEE) wiill be used to measure pulmonary blood flow during surgery visible and successively. To confirm the effect of HPV by measuring the change in pulmonary blood flow. The correlation between the blood oxygen concentration and attenuation of blood flow will be investigated.
Trial information was received from ClinicalTrials.gov and was last updated in August 2016.
Information provided to ClinicalTrials.gov by Juntendo University.