Comparison of Emergence and Oxygenation During One-lung Ventilation With Desflurane and Propofol Anesthesia
This trial is active, not recruiting.
|Collaborator||Baxter Healthcare Corporation|
|Start date||October 2012|
|End date||June 2016|
|Trial size||80 participants|
|Trial identifier||NCT02324283, 12-97|
Which is more adequate general anesthetic agent, desflurane or propofol, for emergence and recovery time, and perioperative oxygenation in lung resection surgery?
|Endpoint classification||efficacy study|
|Intervention model||parallel assignment|
|Masking||single blind (subject)|
time frame: prior to surgery to one-hour after extubation
rapidity of emergence from anesthesia
time frame: one minute after cessation of anethetic agents to one hour after extubation
quality of consiousness
time frame: after extubation
postoperative nausea and vomiting
time frame: on the postoperative day 1
Male or female participants from 20 years up to 75 years old.
- Patients agree to participate in the study
- Patients undergoing lung cancer surgery requiring one-lung ventilation.
- American Society of Anesthesiologists Physical Status Class 1 or 2
- Patients with any of the following will be excluded from lung cancer patients.
- New York Heart Association Classification more than 2
- Respiratory dysfunction Vital Capacity or percent predicted Forced expiratory volume in one second is less than 50 %
- Pulmonary hypertension with mean pulmonary arterial pressure more than 30 mmHg
- Coagulation dysfunction
- The administration of steroids and immunosuppressive agents within 3 months prior to surgery
- Infection with active inflammation
- Pneumonectomy patients
- Cases of epidural anesthesia is contraindicated
|Official title||Comparison of Emergence and Recovery Time, and Evaluation of Oxygenation During One-lung Ventilation With Desflurane and Propofol Anesthesia in Lung Surgery- A Pilot Study|
|Principal investigator||Eiichi Inada, M.D.|
|Description||The investigators plan to investigate the effects of desflurane on oxygenation (prevention of HPV) of OLV compare with propofol which is used in general anesthesia for lung resection. Transesophageal echocardiography (TEE) wiill be used to measure pulmonary blood flow during surgery visible and successively. To confirm the effect of HPV by measuring the change in pulmonary blood flow. The correlation between the blood oxygen concentration and attenuation of blood flow will be investigated.|
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