Overview

This trial is active, not recruiting.

Condition hypertension
Sponsor National Heart, Lung, and Blood Institute (NHLBI)
Collaborator National Human Genome Research Institute (NHGRI)
Start date October 2014
End date July 2030
Trial size 1692 participants
Trial identifier NCT02290392, 15-HG-N011, 999915011

Summary

Background:

- High blood pressure is a common problem. It can cause heart attacks, strokes, and kidney failure. It affects African Americans more than other racial groups. Data were collected from over a thousand African Americans across the country. The data were put into a database (MH-GRID). The data were about genes, diet, sleep, body mass index. They also cover stress and access to healthy foods and parks. Researchers at NIH will study these data in new ways. They want to learn more about the connection between African Americans and high blood pressure.

Objective:

- To study MH-GRID data to find the causes of severe high blood pressure and other cardio-metabolic problems in people of African ancestry.

Eligibility:

- African Americans age 30 55 with severe high blood pressure were used in the MH-GRID study. No new participants will be enrolled in this study.

Design:

- Researchers will examine data from the MH-GRID study.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Time perspective cross-sectional

Primary Outcomes

Measure
The primary outcome variables include severe hypertension and hypertension induced kidney damage.
time frame: On going

Secondary Outcomes

Measure
The secondary outcome variables include obesity, coronary heart disease and metabolic disease syndrome. Intervening variables include genetics, behavioral, ancestry, social, biological, and environmental.
time frame: On going

Eligibility Criteria

Male or female participants from 30 years up to 55 years old.

- INCLUSION CRITERIA: - The MH-GRID Project s inclusion criteria included AA age 30-55 years - Severe controlled HTN or severe resistant HTN. EXCLUSION CRITERIA: - Exclusion criteria involved patients with secondary forms of HTN, primary forms of kidney disease or major co-morbidities (e.g. diabetes, heart failure, end-stage renal failure, HIV, and liver disease). - Children <18 were not enrolled in the protocol.

Additional Information

Official title The Minority Health Genomics and Translational Research BIo-Repository Database (MH-GRID)-2.0
Principal investigator Gary H Gibbons, M.D.
Description The etiology of racial/ethnic differences in health involves dynamic interactions between genetic, behavioral and social-environmental determinants. Despite this, the field lacks robust datasets that integrate these determinants with clinical assessments in minority patient cohorts. The Minority Health Genomics and Translational Research Bio-repository Database (MHGRID) Network infrastructure facilitated the collection of biospecimens and related multidimensional data elements within a consortium of minority-serving clinics. This initiative expands the diversity of ancestral groups in national genomic medicine datasets and promises to accelerate the translation of personalized medicine into minority communities. The MH-GRID project was initiated by Dr. Gibbons (founding PI) prior to becoming an NIH investigator. The MH-GRID project has completed its participant recruitment activities, closed out its NIH funding and now represents an existing dataset and biorepository that is being transferred to NHGRI for ongoing secondary analyses. A variety of investigations will be conducted on this existing dataset. The primary outcome variables include severe hypertension and hypertension induced kidney damage. Secondary outcome variables include obesity, coronary heart disease and metabolic disease syndrome. Intervening variables include genetics, behavioral (i.e. sleep quality, health literacy, smoking, diet, body mass index), ancestry, social (i.e. socioeconomic status, racial discrimination, stress, social depreivation), biological (i.e. insulin resistance, cholesterol, inflammatory markers), and environmental (i.e. neighborhood, access to healthy foods, parks).
Trial information was received from ClinicalTrials.gov and was last updated in August 2016.
Information provided to ClinicalTrials.gov by National Institutes of Health Clinical Center (CC).