Overview

This trial is active, not recruiting.

Conditions hypoalbuminemia, adult icu patient, stewart approach for acid base disorders, human albumin perfusion
Treatment stewart approach
Sponsor University Hospital, Clermont-Ferrand
Start date October 2013
End date November 2014
Trial size 100 participants
Trial identifier NCT02288494, CHU-0204

Summary

The primary purpose was to describe the acid base balance of ICU patients with severe hypoalbuminemia using Stewart's approach for acid base disorders, before and after an human albumin perfusion.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Time perspective cross-sectional
Arm
The primary purpose was to describe the acid base balance of ICU patients with severe hypoalbuminemia using Stewart's approach for acid base disorders, before and after an human albumin perfusion
stewart approach
Prospective study, for ICU patient with severe hypoalbuminemia < 20g/L, determining biological parameters from Stewart approach for acid base disorders (pH, SIDe, SIDa, SIG, Atot, PaCO2) before, and at 1hour, 2hours and 24 hours after a 200mL 20% human al Clinical parameters (respiratory, haemodynamic, neurologic) were also collected at the same times.

Primary Outcomes

Measure
changes in pH and independent pH determinants using Stewart approach
time frame: at 1 hour, 2 hours and 24 hours after a 200mL of 20% human albumin perfusion.

Secondary Outcomes

Measure
changes in neurologic parameters
time frame: at 1 hour, 2 hours and 24 hours after a 200mL of 20% human albumin perfusion.
changes in hemodynamic parameters
time frame: at 1 hour, 2 hours and 24 hours after a 200mL of 20% human albumin perfusion.
changes in respiratory parameters
time frame: at 1 hour, 2 hours and 24 hours after a 200mL of 20% human albumin perfusion.

Eligibility Criteria

Male or female participants at least 18 years old.

Inclusion Criteria: - serum albuminemia < 20g/L - adult ICU patient - Arterial line Exclusion Criteria: - albumin allergy - pregnancy - congestive heart failure

Additional Information

Official title Acid Base Balance of ICU Patients With Severe Hypoalbuminemia, Before and After an Albumin Infusion, Using Stewart Approach
Principal investigator Julien PASCAL
Description Prospective study, for ICU patient with severe hypoalbuminemia < 20g/L, determining biological parameters from Stewart approach for acid base disorders (pH, SIDe, SIDa, SIG, Atot, PaCO2) before, and at 1hour, 2hours and 24 hours after a 200mL 20% human albumin perfusion (the consensus conference ANAES of 1995 recommands to correct hypoalbuminemia below 20g/L). Clinical parameters (respiratory, haemodynamic, neurologic) were also collected at the same times.
Trial information was received from ClinicalTrials.gov and was last updated in November 2014.
Information provided to ClinicalTrials.gov by University Hospital, Clermont-Ferrand.