Genetic and Morphological Analysis of Thyrotoxic Periodic Paralysis
This trial is active, not recruiting.
|Condition||thyrotoxic periodic paralysis|
|Treatment||no intervention involved|
|Sponsor||West China Hospital|
|Start date||October 2014|
|End date||October 2016|
|Trial size||160 participants|
|Trial identifier||NCT02287363, HTian|
The study aims to analyze the genetic variance between thyrotoxic periodic paralysis (TPP) patients and pure hyperthyroidism individuals. Meanwhile, the investigators also intended to evaluate the morphological difference in effected skeletal muscles and investigate their relation with genetic variance.
|Observational model||case control|
Single Nucleotide Polymorphisms
time frame: 2 years
skeletal muscle size of biceps brachii and quadriceps femoris
time frame: 2 years
Male participants from 20 years up to 60 years old.
Inclusion Criteria: A recent history(within three months) of acute limb muscle weakness, hypokalemia and decreased TSH with elevated free FT4, FT3. Exclusion Criteria: Hyperthyroid myopathy with long term muscle weakness, family periodic paralysis, renal tubular acidosis, hyperaldosteronism, hemiplegia, paraplegia, or any history of other metabolic or traumatic muscular disease,
|Official title||Genetic and Morphological Analysis of Thyrotoxic Periodic Paralysis:an Observational Study of Sichuan Individuals in China.|
|Principal investigator||Haoming Tian, MD.|
|Description||Chinese males of their third and forth decades are extremely predisposed to periodic paralysis when they are hyperthyroid. Due to their imbalanced predilection to the disease, genetic variance is considered to be critical to the pathogenesis. In addition, since proximal limb skeletal muscles are the major sites of target, and they are also believed to play a role in the disease generation. Thus, we intend to analyze the genetic and morphological variances between TPP patients and pure hyperthyroidism patients and simultaneously the relation between genetic variance and morphological difference. In this way, we hope to provide evidence for a better understanding of the disease.|
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