Study of the Prognostic Value of Musculoskeletal Ultrasound in Adults With Chikungunya
This trial is active, not recruiting.
|Condition||infected by chikungunya virus|
|Sponsor||Centre Hospitalier Universitaire de Fort-de-France|
|Start date||July 2014|
|End date||January 2015|
|Trial size||200 participants|
|Trial identifier||NCT02281123, 14/B/03, 2014-A00875-42|
Chikungunya is a viral disease transmitted by mosquitoes whose clinical feature is the early joint damage. Approximately 8% of patients have chronic arthropathy resembling to the rheumatoid polyarthritis. The EchoCHIK study we propose is in the context of the epidemic in Martinique which began in January 2014. It should give a better understanding of arthritis and juxtaarticular of CHIK and look for signs that may allow ultrasound predict the evolution of chronic arthropathy of CHIK.
Presence of sonographic signs observed during the initial scan: periarticular infiltration, effusion, positive Doppler, erosions.
time frame: enrollement visit
Presence of clinical and sonographic signs observed at each visit: arthralgia, arthritis clinics, periarticular infiltration, effusion, positive Doppler erosions.
time frame: 1 month, 3 month, 6 month and 12 month after the first symptoms of infection by chikungunya virus
Male or female participants at least 45 years old.
Inclusion Criteria: 1. Age at onset of symptoms ≥ 45 years 2. Seen in consultation at the University Hospital of Fort-de-France 3. Suspected chikungunya infection (fever and sudden onset of joint pain affecting the wrists, hands, ankles or knees) 4. Duration of symptoms suggestive of infection chikungunya less than or equal to 10 days 5. Presence of joint pain on the day of inclusion 6. No history of inflammatory arthritis 7. Absence of steroidal or non-steroidal anti-inflammatory drugs taken within two weeks prior to inclusion 8. Ability to participate in the study throughout its duration (12 months) 9. Patient affiliated or beneficiary of a social health care. 10. Acceptance to participate in the study and monitoring proposed and signed informed consent Exclusion Criteria: 1. Age at onset of symptoms <45 years 2. Duration of symptoms suggestive of chikungunya for more than 10 days 3. Lack of joint pain on the day of inclusion 4. History of inflammatory arthritis Nonsteroidal anti-inflammatory drugs or 5. Taking in the two weeks preceding the inclusion 6. Inability to participate in the study throughout its duration (12 months) 7. Patient is not affiliated or beneficiary of a social health care. 8. Refusal to participate in the study or to sign a consent
|Official title||Study of the Prognostic Value of Musculoskeletal Ultrasound in Adults With Chikungunya|
|Principal investigator||Lauren Brunier-Agot, MD|
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