This trial is active, not recruiting.

Conditions meningoencephalitis, other syndromes requiring lumbar puncture in emergency department
Treatment no intervention
Sponsor Olive View-UCLA Education & Research Institute
Collaborator Centers for Disease Control and Prevention
Start date April 2014
End date July 2016
Trial size 1000 participants
Trial identifier NCT02207647, 12H-770352, U01CK000176


Of all emergency room patients, persons presenting with encephalitis/meningitis syndrome of a potentially infectious nature are among those of greatest concern. Routine clinical and laboratory evaluation of such patients involves screening for known infectious disease agents, selection of which is nonstandardized. Progress in diagnostic technologies, especially molecular techniques based on genetic characteristics of potential pathogens, has greatly expanded the investigators capacity to evaluate specimens from patients for a much wider range of potential pathogens (bacterial, viral, fungal and parasitic agents). Use of Polymerase Chain Reaction (PCR) technology offers the possibility of identifying causative agents for the approximately 50% of all such presentations which go un-diagnosed. The investigators propose a study involving a collaboration between the EMERGEncy ID NET, a network of 10 geographically diverse university-affiliated urban emergency departments (coordinated by Olive View-UCLA Medical Center) and the Centers for Disease Control and Prevention (CDC), to use these new technologies to address this issue.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Observational model ecologic or community
Time perspective prospective
no intervention

Primary Outcomes

prevalence of pathogens
time frame: 2 years

Eligibility Criteria

Male or female participants at least 3 months old.

Inclusion Criteria: - Age > or = 3 months old - Receiving a Lumbar Puncture in the emergency department as part of their standard care. Exclusion Criteria: - No CSF available

Trial information was received from ClinicalTrials.gov and was last updated in August 2016.
Information provided to ClinicalTrials.gov by Olive View-UCLA Education & Research Institute.