Overview

This trial is active, not recruiting.

Condition idiopathic scoliosis
Treatments intraoperative neurophysiologic monitoring, desflurane
Sponsor Children's Hospital Medical Center, Cincinnati
Start date March 2013
End date December 2016
Trial size 30 participants
Trial identifier NCT02199314, 2012-1065

Summary

Test the hypothesis to recruit larger motor responses to transcranial stimulation.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Allocation non-randomized
Intervention model single group assignment
Masking open label
Primary purpose prevention
Arm
(Experimental)
Transcranial motor evoked potentials are obtained once desflurane is at 3%, after desflurane has been on for at least 5 minutes.
intraoperative neurophysiologic monitoring Transcranial Motor Evoked Potentials
transcranial motor evoked potentials are collected prior to the administration of desflurane (under intravenous anesthesia) and again after desflurane is added for at least 5 minutes and is at 3%.
desflurane Suprane
(Experimental)
Transcranial motor evoked potentials are recorded prior to the use of desflurane
intraoperative neurophysiologic monitoring Transcranial Motor Evoked Potentials
transcranial motor evoked potentials are collected prior to the administration of desflurane (under intravenous anesthesia) and again after desflurane is added for at least 5 minutes and is at 3%.
desflurane Suprane

Primary Outcomes

Measure
Area of baseline transcranial motor evoked potentials (TcMEPs) prior to desflurane and after desflurane.
time frame: 15 minutes

Eligibility Criteria

Male or female participants from 12 years up to 17 years old.

Inclusion Criteria: - Age 12 through 17 years - Diagnosis of idiopathic scoliosis - Scheduled for posterior spinal fusion with neurophysiological monitoring - No known allergies to propofol or remifentanil - No contraindication to total intravenous anesthesia - No contraindications to the administration of volatile agents Exclusion Criteria: - Failure to consent or assent to study - Diagnosis other than idiopathic scoliosis - Poorly controlled seizures or the presence of a cochlear implant - Patient history or family history of malignant hypothermia or mitochondrial myopathies

Additional Information

Official title The Effect of Anesthesia on the Recruitment of Motor Evoked Potentials Using an Increased Number of Pulses
Description The study is designed to test the hypothesis that it is possible to recruit larger motor responses to transcranial stimulation by increasing the number of stimulating pulses under both baseline conditions and conditions of increased anesthetic suppression of the motor responses.
Trial information was received from ClinicalTrials.gov and was last updated in September 2016.
Information provided to ClinicalTrials.gov by Children's Hospital Medical Center, Cincinnati.