Overview

This trial is active, not recruiting.

Condition periapical diseases
Treatments metronidazole-ciprofloxacin gatifloxacin-clindamycin paste, creosote
Sponsor Lin Jiacheng
Start date June 2013
End date December 2014
Trial size 100 participants
Trial identifier NCT02196740, Tri-antibiotic-2014

Summary

The triple antibiotic paste is widely used in young permanent teeth and permanent teeth root canal therapy with excellent antiantimicrobial effect.We hypothesize that its application in the treatment of periapical periodontitis of deciduous teeth is superior to other drugs currently in use as creosote.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Allocation randomized
Endpoint classification safety/efficacy study
Intervention model parallel assignment
Masking single blind (subject)
Primary purpose treatment
Arm
(Active Comparator)
Creosote ,once,three weeks Triple Antibiotic Paste ,none
creosote oily liquid obtained by distillation of wood tar
Pulp removal,Root canal irrigation and disinfection
(Experimental)
Triple Antibiotic Paste,once,three weeks creosote,none
metronidazole-ciprofloxacin gatifloxacin-clindamycin paste
Pulp removal,Root canal irrigation and disinfection,

Primary Outcomes

Measure
Evidence of lesion healing confirmed by cone beam computed tomography and X-rays
time frame: 1 year

Eligibility Criteria

Male or female participants from 3 years up to 8 years old.

Inclusion Criteria: - clinical diagnosis of periapical periodontitis - must be primary teeth - must be 3~8 years old - the permanent tooth germ is complete and didnot be involved Exclusion Criteria: - blood disease - residual root that is advised to extract - serious periodontitis - allergy to the triple antibiotic paste

Additional Information

Official title Randomized Controlled Research of the Application of Triple Antibiotic Paste in Primary Teeth With
Description We design to collect a group of patients presenting primary teeth with periapical periodontitis in certain criterion. We will divide the patients into two groups randomly.One group will get treated with triple antibiotic paste while the other with creosote.We want to evaluate the short-term and long-term effects of the two groups to get a conclusion of the clinical value of triple antibiotic paste.
Trial information was received from ClinicalTrials.gov and was last updated in July 2014.
Information provided to ClinicalTrials.gov by Sun Yat-sen University.