This trial is active, not recruiting.

Condition acute kidney injury
Sponsor Stanford University
Start date July 2013
End date June 2015
Trial size 1500 participants
Trial identifier NCT02188602, 27752


The investigators would like to investigate the effect of chloride dosing on the development of acute kidney injury in critically ill patients. The investigators hypothesis is that administering intravenous fluids with higher chloride content are more likely to lead to acute kidney injury.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Observational model cohort
Time perspective retrospective
Patients receiving high dosing of chloride
Patients receiving low dosing of chloride

Primary Outcomes

Acute Kidney Injury
time frame: 7 days

Secondary Outcomes

PICU length of stay
time frame: 7 days
Hospital length of stay
time frame: 7 days
Number of ventilator days
time frame: 7 days
time frame: 7 days

Eligibility Criteria

Male or female participants from 1 month up to 18 years old.

Inclusion Criteria: - age less than 18 years - PICU admitting diagnosis of sepsis, respiratory failure, or hepatic failure. Exclusion Criteria: - hyponatremia or hypernatremia at PICU admission - preexisting diagnosis of End-stage renal disease or renal transplant - presence of neurologic comorbidities.

Additional Information

Official title Retrospective Investigation of Chloride Dosing and Its Effect on Acute Kidney Injury
Principal investigator Weiwen V Shih, MD
Description Retrospective chart review from 2008-2012 evaluating chloride dosing and serum chloride levels and their effects on acute kidney injury in the pediatric ICU. Patients will be included for the first seven days of their PICU stay.
Trial information was received from ClinicalTrials.gov and was last updated in July 2014.
Information provided to ClinicalTrials.gov by Stanford University.