Predicting Normal vs. Carrier Status in Euploid Embryos of Translocation Carriers
This trial is active, not recruiting.
|Condition||balanced chromosomal translocation|
|Sponsor||Reproductive Medicine Associates of New Jersey|
|Start date||June 2014|
|End date||November 2016|
|Trial size||100 participants|
|Trial identifier||NCT02178865, RMA-2014-01|
The purpose of this study is to assess the accuracy of predicting the normal or carrier status of human embryos resulting from in vitro-fertilization (IVF) from patients carrying a balanced translocation.
balanced translocation carriers who have undergone IVF
Proportion of correct predictions of normal vs. balanced ploidy status as compared to conventional karyotype
time frame: up to 12 months once pregnant
Male or female participants at least 7 years old.
- patients with balanced translocations who have undergone IVF
- those who do not wish to know their child(s) karyotype
|Official title||Evaluation of the Accuracy of Predicting Normal or Carrier Status in Euploid Embryos Produced by Patients With Balanced Translocations|
|Principal investigator||Richard T Scott, MD, HCLD|
|Description||This study aims to evaluate the validity of using informative SNPs to distinguish balanced from normal embryos. This will involve acquiring material from families to set phase for informative SNPs, evaluation of existing and new embryo SNP array data, and follow up analysis of children born after applying the procedure.|
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