Magnetic Resonance Imaging in Myocarditis
This trial is active, not recruiting.
|Sponsor||University of Leipzig|
|Start date||August 2012|
|End date||December 2015|
|Trial size||120 participants|
|Trial identifier||NCT02177630, 123456123456|
The purpose of this study is the assess the diagnostic performance of magnetic resonance imaging in patients with suspected myocarditis by applying different imaging sequences at different MR scanners
Magnetic resonance imaging and endomyocardial biopsy
Accuracy, sensitivity and specificity of magnetic resonance imaging sequences
time frame: baseline
Diagnostic performance of biventricular endomyocardial biopsies
time frame: baseline
Male or female participants from 18 years up to 80 years old.
Inclusion Criteria: Symptoms such as: - Dyspnea or Orthopnea or - Palpitations or - Exercise intolerance or - Angina Evidence of myocardial involvement: - ventricular dysfunction on echocardiography or - new or persistent ECG changes - elevated Troponin T History of viral infection Exclusion Criteria: - Contraindication for magnetic resonance imaging - Impaired renal function: glomerular filtration rate ≤ 30 ml/min/m2 - Patients presenting with pregnancy - Patients without informed consent - Participation in another trial.
|Official title||Myocarditis and the Role of Advanced Magnetic Resonance Imaging|
|Principal investigator||Philipp Lurz, MD, PhD|
|Description||In patients with clinical suspicion of myocarditis biventricular endomyocardial biopsy is performed for definite diagnosis. In addition, patients undergo magnetic resonance imaging at 1.5 Tesla and 3.0 Tesla within 24 hours. The imaging protocol of both scan include assessment of myocardial edema respectively edema ratio; myocardial hyperemia respectively global relative enhancement (gRE); myocardial fibrosis/necrosis respectively myocardial LE and T1 and T2 mapping sentences. Diagnostic performance of different imaging protocols as compared to the findings of endomyocardial biopsies is calculated. The protocol also includes a follow-up MR can at 3 months.|
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