This trial is active, not recruiting.

Condition sjogren syndrome
Treatment speckle tracking echocardiography
Sponsor University of Roma La Sapienza
Start date January 2010
End date March 2013
Trial size 700 participants
Trial identifier NCT02132585, Spk-001


Speckle tracking (STE) is a novel echocardiographic technique which permits calculation of myocardial velocities and deformation parameters such as strain and strain rate (SR). It is demonstrated that these parameters provide important insights into systolic and diastolic function, ischaemia, myocardial mechanics and many other pathophysiological processes of the heart. In this preliminary study, we investigated the role of STE in detection of early ventricular dysfunction in patients with Sjogren Syndrome, focusing on cardiorespiratory fitness.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Observational model case control
Time perspective cross-sectional
Sjogren Patients evaluated with Speckle tracking echocardiography
speckle tracking echocardiography
Controls Speckle tracking echocardiography
speckle tracking echocardiography

Primary Outcomes

Longitudinal Myocardial Strain reduction in Sjogren Patients
time frame: Baseline, 24 weeks

Secondary Outcomes

Association between 6minute-walking-test and Longitudinal strain reduction
time frame: baseline, 24 weeks

Eligibility Criteria

Male or female participants from 40 years up to 75 years old.

Inclusion Criteria: - Diagnosis of Sjogren Syndrome Exclusion Criteria: - previous cardiovascular events - unstable angina - stroke - diagnosis of heart failure - incapacity to provide an informed consent

Additional Information

Official title Cross Sectional Study of Use of Speckle Tracking Echocardiography in the Early Diagnosis of Cardiovascular Dysfunction and Performance in Sjogren Patients
Trial information was received from ClinicalTrials.gov and was last updated in May 2014.
Information provided to ClinicalTrials.gov by University of Roma La Sapienza.