A Randomized Trial of Intracoronary Reopro to Improve Coronary Microvascular Function
This trial is active, not recruiting.
|Conditions||myocardial infarction, coronary artery disease|
|Sponsor||University of Melbourne|
|Start date||February 2012|
|End date||June 2014|
|Trial size||40 participants|
|Trial identifier||NCT02105870, SVH 001|
Microvascular dysfunction is a key determinant of pathogenesis and outcome in patients suffering an acute myocardial infarction.
The investigators hypothesise that treatment with intracoronary abciximab, a potent anti platelet agent, at the time of coronary stent insertion, will improve microvascular function.
|Endpoint classification||safety/efficacy study|
|Intervention model||parallel assignment|
|Masking||double blind (subject, caregiver, investigator, outcomes assessor)|
Intracoronary abciximab (Reopro)
Index of Microvascular Resistance
time frame: within 3 hours
Incidence of periprocedural myocardial infarction
time frame: within 24 hours
Male or female participants from 18 years up to 85 years old.
Inclusion Criteria: - Patient with acute coronary syndromes Exclusion Criteria: - Patient with untreated malignancy, disseminated malignancy, active inflammatory diseases, active infectious diseases patients unable to give informed consent Patients with STEMI
|Official title||A Randomized Control Trial of Intracoronary Reopro to Improve Coronary Microvascular Function|
|Principal investigator||Andrew Wilson, MD PhD|
|Description||The index of microcirculatory resistance (IMR), an invasive measure of coronary microvascular function, correlates with clinical outcomes in patients with stable angina and ST elevation myocardial infarction. The glycoprotein IIb/IIIa receptor inhibitor, abciximab, improves coronary microvascular function and reduces major cardiac adverse events in patients with acute coronary syndromes. This study will investigate whether an intracoronary bolus of abciximab in patients with non-ST elevation myocardial infarction decreases IMR and improves microvascular function.|
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