This trial is active, not recruiting.

Condition atopic dermatitis
Sponsor Columbia University
Collaborator Society for Pediatric Dermatology
Start date December 2011
End date December 2016
Trial size 114 participants
Trial identifier NCT02091037, AAAI5956


The purpose of this study is to characterize the bacterial strains that colonize children with atopic dermatitis.

The investigators hypothesize that rectal cultures will be more sensitive than anterior nares cultures for detecting S. aureus colonization, and that strains of S. aureus colonizing patients with atopic dermatitis will be resistant to commonly used topical antibiotic ointments.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Observational model case-only
Time perspective cross-sectional

Primary Outcomes

Difference in rectal and nasal S. aureus colonization rates in a population of children with atopic dermatitis
time frame: Up to 3 years

Secondary Outcomes

Rates of resistance to commonly used topical antibiotic ointments in strains of S. aureus that colonize a population of children with atopic dermatitis
time frame: Up to 20 years

Eligibility Criteria

All participants up to 18 years old.

Inclusion Criteria: - subjects with a diagnosis of atopic dermatitis seen by the Columbia University Medical Center department of dermatology - subjects ages 0 to 18 years Exclusion Criteria: - those patients in which a definitive diagnosis of AD cannot be made - subjects over the age of 18 years old - subjects with evidence of acute systemic illness - subjects currently taking systemic antibiotics - subjects with viral or fungal skin infection - any individual who declines participation

Additional Information

Official title Staphylococcus Aureus Colonization in Atopic Dermatitis
Description Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by pruritis and eczematous lesions with a worldwide prevalence of 15-20%. The burden of disease is highest in the most developed nations and predominantly affects children, with 50% of cases arising in the first year of life, and most others arising in the first 5 years. There is a well-known increased susceptibility to skin infection with S. aureus in patients with AD, and such infections are associated with clinical deterioration. While it is routine to evaluate for S. aureus colonization in the anterior nares, there is recent evidence suggesting that rectal colonization may be more significant. The significance of colonization site has not been evaluated in the AD population. Additionally, while topical antibiotics are a mainstay of treatment in AD, there is no routine data on the resistance to these agents. Our aim is to characterize the S. aureus colonization patterns in children with AD, including site of colonization and antibiotic resistance. We will analyze routinely-collected skin culture specimens from children with AD seen at our center and determine antibiotic susceptibility profiles. The significance of colonization site will be analyzed.
Trial information was received from ClinicalTrials.gov and was last updated in January 2017.
Information provided to ClinicalTrials.gov by Columbia University.